BBH 451 Pharmacodynamics Review Questions and Correct Answers
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Course
BBH 451
Institution
BBH 451
Pharmacodynamics The study of what the drug does to the body
-drug receptor interactions
After drugs bind to receptor sites they can... induce or block alterations of shape
Agonism the drug mimics the effects of neurotransmitter
Antagonism the drug prevents action that would normally be c...
BBH 451 Pharmacodynamics Review
Questions and Correct Answers
Pharmacodynamics ✅The study of what the drug does to the body
-drug receptor interactions
After drugs bind to receptor sites they can... ✅induce or block alterations of shape
Agonism ✅the drug mimics the effects of neurotransmitter
Antagonism ✅the drug prevents action that would normally be carried out when a drug
binds to a receptor
inverse agonism ✅binds to the inactive form of a receptor and shifts the equilibrium so
that the opposite response to an agonist is produced (from baseline)
GPCRs ✅metabotropic receptors that activate G-proteins which have a variety of
actions
-often activate second messengers
Which two Amercian scientists shared this year's Nobel Prize for deciphering the
communication system that the human body uses to send messages to the cells?
✅Robert Lefkowitz and Brain Kobilka
psychoactive drugs ✅chemicals that affect the central nervous system and alter
activity in the brain
-mimic or block actions of basic neurotransmitters
AG1 (DRUG) ✅competitive agonism
-because it works to get to the same sight as the endogenous ligand
-fit into same space so have same activity and consequence between drug and ligand
AG2 ✅non competitive it fits into the slot so it induces the same change as the
neurotransmitter (ligand)
What is the initial action of a drug (ligand) binding to a receptor? ✅the receptor
changes shape
-cannot get any signaling unless the shape is changed which is same with endogenous
Norephinephrine (NE) Receptor Schematic ✅GPCR threads through the membrane 7
times
-length and sequence of actual extracellular parts and different amount of amino acid
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