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LECTURE: GENETIC ANCESTRY QUESTIONS AND ANSWERS WITH SOLUTIONS 2024
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LECTURE: GENETIC ANCESTRY QUESTIONS AND ANSWERS WITH SOLUTIONS 2024
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LECTURE: GENETIC ANCESTRYQUESTIONS AND ANSWERS WITH
SOLUTIONS 2024
Genetic ancestry testing provides - ANSWER Genealogical history
Geographic history
Population affiliations
Tools for inferring genetic ancestry - ANSWER Lineage and autosomal genetic ancestry
Maternal Lineage - ANSWER Genetic component passed through the female lines of a family
(mitochondrial DNA) mtDNA
Paternal lineage - ANSWER Genetic component passed through the male lines of a family (Y-
chromosome) -NRY
How do you determine Autosomal genetic ancestry - ANSWER Ancestry Informative Markers (AIMs)
Whole Genome Scans
What are AIMs - ANSWER A set of polymorphisms for a locus which exhibits substantially different
frequencies between populations from different geographical regions (e.g. Lactose persistence)
AIMs population differentiation - ANSWER About 5% of genetic markers have higher Fst than expected
AIMs with Fst > 0.5 considered sufficient for ancestry differentiation
When does Genetic Admixture occur - ANSWER Occurs when two or more previously isolated
populations begin interbreeding
Admixture - ANSWER Results in the intro of new genetic lineages into a population
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