Principles of Human Heredity Exam 2 Questions & 100% correct AnswersLatest Test | Graded A+ | Passed
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Course
Principles of Human Heredity
Institution
Principles Of Human Heredity
Mode of Inheritance
Ξ -:- Autosomal recessive
Ξ Autosomal dominant
Ξ X-linked dominant
Ξ X-linked recessive
Ξ Y-linked Mitochondrial
Genotypic ratios persist but phenotypic ratios may vary due to:
Ξ -:- .Alleles interacting with each other
Ξ .Genes interacting with other genes and t...
, E x c e l l e n c e i s k e y | 2 0 2 0 2 5 ~ P a g e |2
Ξ a= normal height
Ξ A= achondroplasia
Multiple alleles
Ξ -:- .alternate forms of the same gene that influence the same trait
Ξ . while an individual carries two alleles per gene for each autosomal gene, the
population can contain many alleles for a given gene
. The different allele combinations often produce variations in the phenotype
Incomplete dominance
Ξ -:- .Heterozygous phenotype is between those of the two homozygotes
FAMILIAL HYPERCHOLESTEROLEMIA (FH)Heterozygote has approximately half the normal
number of receptors in the liver for LDL cholesterol
Homozygous for the mutant allele totally lacks the receptor, and so their serum cholesterol level is
very high
Codominant Alleles
Ξ -:- .Heterozygous phenotype results from the expression of both alleles.
EXAMPLE: ABO gene encodes a cell surface protein. IA allele produces A antigen. IB allele produces
B antigen. i (IO) allele does not produce antigens. Alleles IA and IB are codominant, and both are
completely dominant to i.
Epistasis
Ξ -:- When one gene affects the expression of a second gene.
EXAMPLE: Bombay phenotype
H gene is epistatic to the I gene. The H protein is a cell surface protein to which the A or B antigens
are attached. The hh genotype = no H protein expressed. Without H protein the A or B antigens can
not be attached to the surface of the RBC. All hh genotypes have the phenotype of type O, although
the ABO blood group can be anything (A, B, AB, or O)
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