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DOSAGE FORMS EXAM 3 - MCPHS QUESTIONS & ANSWERS VERIFIED 100% CORRECT $7.99
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DOSAGE FORMS EXAM 3 - MCPHS QUESTIONS & ANSWERS VERIFIED 100% CORRECT
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What decreases water solubility? - Increasing # of C atoms in a molecule and increased molecular weight Clinical Phase III - Studies benefit/risk relationship of drug, less common/longer term side effects, and labeling information on a very large group of patients Active Pharmaceutical Ingredie...

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  • August 27, 2024
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  • 2024/2025
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DOSAGE FORMS EXAM 3 - MCPHS
What decreases water solubility? - Increasing # of C atoms in a molecule and increased molecular
weight



Clinical Phase III - Studies benefit/risk relationship of drug, less common/longer term side effects,
and labeling information on a very large group of patients



Active Pharmaceutical Ingredient - Any component that is intended to cause pharmacologic
activity or other direct drug effects



Pharmaceutics - General area of study concerned with the formulation, manufacture, stability and
effectiveness of pharmaceutical dosage forms



Drug - any agent intended for use in the diagnosis, mitigation, treatment, cure or prevention of
disease in humans or other animals



Broad steps of new drug development - 1) Drug Discovery

2) Animal Studies

3) Clinical Tests

4) Commercialization



In silico screening - Biological experimentation performed by a computer



Drug discovery methods - 1) Screening natural compounds

2) Screening corporate compounds

3) In silico screening

4) Rational drug design

5) Combinatorial chemistry

, Combinatorial Chemistry - Preparation of a large number of different compounds at the same
time



ADMET - Absorption

Distribution

Metabolism

Excretion

Toxicity



Absorption (testing) - To see that the drug passes GI track into blood stream



Distribution (testing) - To see that the the drug gets to target tissue



Metabolism (testing) - To see that the drug is not readily metabolized



Excretion (testing) - To see that the drug is not readily secreted



Toxicity (testing) - To see that the drug is not toxic to other cells or tissue



Biologic Pre-clinical Tests - Pharmacology, Drug metabolism and toxicology experiments



Preformulation Studies - 1) Drug solubility

2) Partition coefficient

3) Dissolution rate

4) Physical form

5) Stability



Clinical Phase I - Study's absorption/metabolism, effects on organs and tissue and side effects on
~20-100 healthy volunteers

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