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TOX EXAM QUESTIONS AND ANSWERS
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TOX EXAM QUESTIONS AND ANSWERS
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TOX EXAMQUESTIONS
AND ANSWERS
Which one of the following statements regarding toxicology is true
A. Modern toxicology is concerned with the study of the adverse effects of chemicals on
ancient forms of life
B. Modern toxicology studies embrace principles from such disciplines as biochemistry
botany chemistry physiology and physics
C. Modern toxicology has its roots in the knowledge of plants and animal poison which
predates recorded history and has been used to promote peace
D. Modern toxicology studies the mechanisms by which inorganic chemicals produced
advantageous as well as deleterious effects
E. Modern toxicology is concerned with the study of chemicals in mammalian species -
Answers -B. modern toxicology studies embrace principles from such disciplines as
biochemistry, botany, chemistry, physiology, and physics
Knowledge of toxicology of poisonous agents was published earliest in the
A. Ebers papyrus
B. De historia plantarum
C. De materia médica
D. Lex Cornelia
E. Treatise on poisons and their antidotes - Answers -A. Ebers papyrus
Paracelsus, a physician-alchemist, formulated many revolutionary views that remain
integral to the structure of toxicology, and therapeutics today. He focused Primarily on
the toxic agent as a chemical entity and articulated the dose-response relation. Which
one of the following statements is not attributable to Paracelsus?
A. Natural poisons are quick in their onset of actions
B. Experimentation is essential in the examination of responses the chemicals
, C. When should make a distinction between the therapeutic and toxic properties of
chemicals
D. These properties are sometimes but not always indistinguishable except by dose
E. One can ascertain a degree of specificity of chemicals in there therapeutic or toxic
effects - Answers -A. Natural poisons are quick in their onset of actions
The art of toxicology requires years of experience to acquire, even though the
knowledge base of facts may be learned more quickly. Which modern toxicologist is
credited with saying that "you can be a toxicologist in two easy lessons, each 10
years?"
A. Claude Bernard
B. Rachel Carson
C. Upton Sinclair
D. Arnold Lehman
E. Oswald schmiedberg - Answers -D. Arnold Lehman
Which of the following statements is correct?
A. Claude Bernard was a prolific scientist who trained over 120 students and published
numerous contributions to the scientific literature
B. Louis Louis and trained under Oswald Schmiedeberg and published much of the
early work on toxicology of narcotics, methanol and chloroform
C. An introduction to the study of experimental medicine was written by the Spanish
physician Orfila
D. Magendie do you use autopsy material and chemical analysis systematically as legal
proof of poisoning
E. Percival Potts was instrumental in demonstrating the chemical complexity of snake
venom - Answers -B. Louis Lewin trained under Oswald Schmiedeberg and published
much of the early work on the toxicology of narcotics, methanol, and chloroform
Five almost identical experimental animals are treated with 1 mg of one of the following
toxins. The animal treated with which toxin is most likely to die?
A. Ethyl alcohol (LD50= 10,000 mg/kg)
B. Botulinum toxin (LD50= 0.00001mg/kg)
C. Nicotine (LD50= 1mg/kg)
D. Ferrous sulfate (LD50 = 1500 mg/kg)
E. Picrotoxin (LD50 = 5 mg/kg) - Answers -B. botulinum toxin ( LD 50 = 0.00001 mg/kg)
Place the following mechanism of toxin delivery in order from most effective to least
effective - 1: intravenous; 2: subcutaneous; 3: oral; 4: inhalation; 5: dermal
A. 1,5,2,4,3
B. 4,1,2,3,5
C. 1,4,2,3,5
D. 4,2,1,5,3
E. 1,4,3,2,5 - Answers -C. 1,4,2,3,5
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