UAMS Hematology Exam 6 Questions & Answers 2024/2025
PTT - ANSWERSWhat is the intrinsic system tested with?
PT - ANSWERSWhat is the extrinsic system tested by?
HMW kininogen and prekalikrein activate the extrinsic, whereas exposed collagen that releases thromboplastin activates the intri...
PTT - ANSWERSWhat is the intrinsic system tested with?
PT - ANSWERSWhat is the extrinsic system tested by?
HMW kininogen and prekalikrein activate the extrinsic, whereas exposed collagen that releases
thromboplastin activates the intrinsic pathway. - ANSWERSWhat activates the extrinsic pathway? What
about the intrinsic pathway?
PT and PTT - ANSWERSWhat is the common system tested by?
2, 7, 9, and 10 - ANSWERSWhat factors are associated with Factor K?
1, 5, 8, 13, and 2 - ANSWERSWhat are the consumable factors?
Hemostasis - ANSWERSWhat is the process of keeping blood in the fluid state unless clotting occurs due
to vascular injury?
Primary hemostasis is the platelet plug formed on damaged vessels, whereas secondary hemostasis is
the fibrin formation from plasma factors. - ANSWERSWhat is the difference between primary and
secondary hemostasis?
To form an endothelial layer and prevent RBCs from escaping. The release of exposed substances such as
collagen and Von Willebrands factor causes a break in the system allowing RBCs to escape which causing
bleeding and bruising. Vasoconstriction occurs to stop the blood flow. - ANSWERSWhat is the role of the
vascular system? What causes a break in this system? What puts a stop to this?
, Bruising, petechiae, and mucous membrane bleeding - ANSWERSWhat are the vascular disorder
symptoms?
Inherited, often hereditary teleangiectasia and acquired, often from drugs such as steroids, estrogen, or
just from age - ANSWERSWhat are the two categories for vascular disorder?
Megakaryocytes, produced in the bone marrow. It is the only cell that gets bigger as it matures. -
ANSWERSWhat is the parent cell to platelets and where is it produced? What is unique about this cell?
Thrombopoietin and CSF - ANSWERSWhat influences the number and size of megakaryocytes?
Endomitosis, megakaryocytes - ANSWERSWhat is the doubling of DNA without cell division? What cell
does this?
When the filament extends through the endothelial cells and fragments into the cells. - ANSWERSWhen
do platelets get into the blood?
2/3, the rest are stored in the spleen. If a splenectomy is performed, the platelet count goes up. 8-12
days. - ANSWERSHow many platelets circulate in the blood? Where are the rest stored? What is the
lifespan of platelets?
Platelet plasma membrane or peripheral zone - contains the glycocalyx that is a receptor for various
glycoproteins and phospholipids.
Platelet cytoskeleton / structural zone or sol-gel zone - contains the cytoskeletal and microtubules -
ANSWERSWhat are the platelet zones and what does each contain?
Collagen. Von Willebrand factor. Fibrinogen. Phospholipids are necessary for the activation of the
intrinsic system and keeps the reactions localized. - ANSWERSIn the peripheral zone where the glycocalyx
is located, what does glycoprotein Ia/IIa and VI bind to? What does glycoprotein Ib/IV/V that is involved
with platelet adhesion bind to? What does glycoprotein IIb/IIIa that is involved with platelet aggregation
bind to? What are phospholipids necessary for?
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