Exam (elaborations)
USMLE STEP 1 RAPID REVIEW
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USMLE STEP 1 RAPID REVIEW
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USMLE STEP 1 RAPID REVIEWAbdominal pain, ascites, hepatomegaly, (also high D dimer, CHF without JVD) -
Answers -Budd-Chiari syndrome
Achilles tendon xanthoma - Answers -Familial hypercholesterolemia
Adrenal hemorrhage, hypotension, DIC - Answers -Waterhouse-Friderichsen syndrome
(meningococcemia)
Arachnodactyly, lens dislocation, aortic dissection, hyperflexible joints - Answers -
Marfan's (fibrillin defect)
Athlete with polycythemia - Answers -Erythropoietin injection
Back pain, fever, night sweats, weight loss - Answers -Pott's (TB to the vertebrae)
Bilateral hilar adenopathy, uveitis - Answers -Sarcoid
Blue sclera - Answers -Osteogenesis imperfecta
Bluish line on gingiva - Answers -Burton's line - lead poisoning
Bone pain, bone enlargement, arthritis, (also increased hat size, fracture, increased alk
phos) - Answers -Paget's
Bounding pulses, diastolic hear murmur, head bobbing - Answers -Aortic regurg
Café-au-lait spots, Lisch nodules - Answers -NF (1 = optic glimoas and pheo, 2 =
acoustic Schwannomas)
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty - Answers -
McCune-Albright syndome (G protein problem)
Calf pseudohypertrophy - Answers -Duchenne's muscular dystrophy
Cherry-red spot on macula - Answers -Tay-Sachs, Niemann-Pick, central retinal artery
occlusion
Chest pain, pericardial effusion/friction rub, persistent fever following MI - Answers -
Dressler's (autoimmune post-MI)
Child uses arms to stand up from squat - Answers -Gower's sign (Duchenne's)
Child with fever develops red rash on face that spreads to body - Answers -Slapped
cheek - B19
, Chorea, dementia, caudate degeneration - Answers -Huntington's
Chronic exercise intolerance with myalgia, fatigue, painful cramps - Answers -McArdle's
(muscle phosphorylase deficiency)
Cold intolerance - Answers -Hypothyroidism
Hereditary nephritis, sensorineural hearing loss, cataracts - Answers -Alport's syndrome
(type IV collagen)
Hypercoagulability leading to thrombophlebitis - Answers -Trousseau's sign
(adenocarcinoma of pancreas or lung)
Hyperphagia, hypersexuality, hyperorality, hyperdocility - Answers -Kluver-Bucy
syndrome (bilateral amygdala)
HTN, hypoK, metabolic alkalosis - Answers -Conn's (1* hyperaldosterone)
Hypoxemia, polycythemia, hypercapnia - Answers -Blue bloater (chronic bronchitis)
Indurated, ulcerated genital lesion - Answers -Nonpainful = syphillis. Painful with
exudate = chancroid
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration - Answers -
Niemann-Pick disease (genetic sphingomyelinase deficiency)
Infant with hypoglycemia, failure to thrive, and hepatomegaly - Answers -Cori's disease
(debranching enzyme deficiency, no glycogenolysis) or Von Gierke's
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart
defect - Answers -Edward's syndrome (Trisomy 18)
Jaundice, RUQ pain, fever - Answers -Charcot's triad (ascending cholangitis)
Keratin pearls - Answers -Squamous cell carcinoma
Large rash with bull's eye appearance - Answers -Erythema chronicum migrans from
Ixodes tick bite (Lyme)
Lucid interval after TBI - Answers -Epidural hematoma (middle meningeal artery)
Male child, recurrent infections, no mature B cells - Answers -Bruton's disease (X-linked
agammaglobulinemia)
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