Pharmacology Test Bank Exam Questions And Correct Answers
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Course
Pharmacology
Institution
Pharmacology
Pharmacology Test Bank Exam Questions
And Correct Answers
The pKa (for the COOH group) of each of the three drugs is as follows: thyroxine = 3.0,
mesothyroxine = 4.0, neothyroxine = 5.0. Of these, which will be absorbed to the greatest extent
from the stomach (pH = 1.0)? - answerneothyroxine
T...
Pharmacology Test Bank Exam Questions
And Correct Answers
The pKa (for the COOH group) of each of the three drugs is as follows: thyroxine = 3.0,
mesothyroxine = 4.0, neothyroxine = 5.0. Of these, which will be absorbed to the greatest extent
from the stomach (pH = 1.0)? - answer✔✔neothyroxine
The multi drug resistance proteins (or p-glycoproteins) can protect liver and kidney cells by
exporting harmful chemicals against a concentration gradient in an energy-dependent manner.
What is this called? - answer✔✔active transport
Phase II conjugates typically have the following property/properties - answer✔✔rapidly excreted
in the urine
A drug with a half-life of 2 hours is administered by continuous intravenous infusion. How long
will it take for the drug to reach 50% of its steady state concentration? - answer✔✔2 hours
Caffeine is eliminated primarily by metabolism and with first order kinetics. The half-life of
caffeine varies significantly with individuals, but is on average 5.0 hours. The volume of
distribution is 0.60 L/kg. Joe has a mass of 70 kg and is an average subject with regard to
caffeine pharmacokinetics. He has a regular habit of consuming a cup of coffee (85 mg of
caffeine) at 8 am.
What is the clearance value (CL) of caffeine in a normal individual? - answer✔✔0.083 L/hr/kg
Which of the following routes is most likely to be affected by the first-pass effect? -
answer✔✔oral
A drug, given as a 150 mg single dose, results in a peak plasma concentration of 10 ug/mL. The
apparent volume of distribution is (rapid distribution and negligible elimination prior to
measuring the peak plasma level): - answer✔✔15 L
Which of the following are routes of drug clearance?
-renal
-sweat
What factor(s) may reduce drug bioavailability?
-gastric acid instability
-first-pass affect
-exposure to digestive enzymes - answer✔✔all of the above
What type of receptor is the muscarinic receptor? - answer✔✔G-protein coupled receptor
For a cholinesterase modified by an organophosphate compound (e.g. soman), what is the time-
dependent dealkylation process called yielding an enzyme refractory toward reactivation? -
answer✔✔aging
Muscarinic receptors bind - answer✔✔acetylcholine
Which of the following is a clinical use for a muscarinic agonist? - answer✔✔"switching on" the
urinary tract after surgery
Indirect cholinergic agonists cause - answer✔✔inhibition of acetylcholinesterase and a
corresponding increase in the synaptic acetylcholine levels
Which of the following is characteristic of the sympathetic nervous system? -
answer✔✔responded predominate during physical activity or when experiencing fright
A patient with an acute attack of glaucoma is treated with pilocarpine. The primary reason for its
effectiveness in this condition is its: - answer✔✔ability to lower intraocular pressure
Put the following steps in the correct order for neurotransmission at the cholinergic neuron -
answer✔✔1. acetylcholine is synthesized from choline and acetyl-CoA
2. acetylcholine is released from storage vesicles into the synaptic cleft
3. acetylcholine is synthesized from choline and acetyl-CoA
4. acetylcholine is degraded by acetylcholinesterase
The autonomic nervous system innervates all of these except - answer✔✔skeletal muscle
A soldiers' unit has come under attack with a nerve agent. The symptoms exhibited are skeletal
muscle paralysis, profuse brachial secretions, miosis, bradycardia, and convulsions. The alarm
indicates exposure to an organophosphate. What is the correct treatment? - answer✔✔administer
atropine and 2-PAM (pralidoxime)
a study examining how a drug is distributed throughout the body and how the drug is changed
before eliminated is an example of - answer✔✔pharmacokinetics
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