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Exam (elaborations)

BIO 235 Exam 4 questions and answers

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  • BIO 235

Helicase - Unwinds DNA in both directions Gyrase - topoisomerase that relieves supercoiling ahead of replication fork Single Stranded Binding proteins do what? - Stabilize single stranded DNA Primase - Enzyme that makes RNA primers DNA polymerase cannot? - Reconstruct the 5' end of a DN...

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  • August 29, 2024
  • 15
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • BIO 235
  • BIO 235
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BIO 235 Exam 4 questions and answers
Helicase - Unwinds DNA in both directions


Gyrase - topoisomerase that relieves supercoiling ahead of replication fork


Single Stranded Binding proteins do what? - Stabilize single stranded DNA


Primase - Enzyme that makes RNA primers


DNA polymerase cannot? - Reconstruct the 5' end of a DNA strand


this poses problems for linear chromosome integrity


Telomeres - Repetitive DNA sequences TTAGGG
-no protein coding
-binds two types


Two types of proteins that binds in telomeres - -Protective proteins
-telomerase enzyme


Telomerase enzyme - ribonucleoprotein


ribonucleoprotein - composed of RNA and protein

, Binding of telomerase to TTAGGG - Addition of RNA extends ends
-carries its own DNA template as well....to finish DNA strand


Telomerase is key in determining what? - Life-span of cell


Telomerase in immortalized cells - ie germ line, cancer, yeast...


-Telomeres are fully reconstructed with each DNA replication


Telomerase in somatic cells - Virtually absent
-shortened with every cell division
-somatic cells divide 30-50 times then die


in yeast, deletion of telomerase gene leads to what? - Shortening of chromosomes
at each cell division


Telomerase activity in cancer cells? - High activity


Telomerase activity in somatic cells which cancer derives? - low activity or absent


If you can block telomerase activity, you can do what? - STOP CANCER!


Nobel prize in medicine: - Elizabeth Blackburn, Carol Greider, Jack Szostak.


-Protection of chromosomes by the telomerase enzyme

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