Nurs 615 Pharm Exam 1 – Maryville
Practice Questions and Answers
How does hypoalbuminemia affect the process of prescribing? -
Answer️️ -Low albumin = more free drug (bc the drug can't bind to
albumin aka protein) = increased adverse effects
What is a Black Box Warning: - Answer️️ -i...
Nurs 615 Pharm Exam 1 – Maryville
Practice Questions and Answers
How does hypoalbuminemia affect the process of prescribing? -
Answer✔️✔️-Low albumin = more free drug (bc the drug can't bind to
albumin aka protein) = increased adverse effects
What is a Black Box Warning: - Answer✔️✔️-is considered a
contraindication to administer that drug.
What is the drugs half-life? - Answer✔️✔️-Half-life specifically means the
amount of time it takes for an administered drug to be halfway cleared
from the system.
Peak of action: - Answer✔️✔️-the time between drug administration and
maximum concentration of drug in the blood stream. Best therapeutic
effect.
Duration of action: - Answer✔️✔️-the time between onset of action and
metabolism of drug below the minimum needed for an effect. The length of
time you have the drug in your system.
According to the WHO what is the first step in the prescribing process? -
Answer✔️✔️-The first step is to define the patient's problem
The second step is to - Answer✔️✔️-specify the therapeutic objective
The third step is to - Answer✔️✔️-choose which drug or treatment is needed.
Step 4 of the WHO approach: - Answer✔️✔️-Start the treatment
Step 5 of the WHO approach: - Answer✔️✔️-Educate the patient
Step 6 of the WHO approach: - Answer✔️✔️-Monitor the treatment
Phase 1 of drug development: - Answer✔️✔️-The drug is tested on healthy
volunteers
Phase 2 of drug development: - Answer✔️✔️-trials with people who have
the disease for which the drug is thought to be effective
Phase 3 of drug development: - Answer✔️✔️-Large numbers of patients in
medical research centers receive the drug in phase 3. This larger sampling
provides information about infrequent or rare adverse effects. The FFA will
approve a new drug application if phase 3 studies are satisfactory.
Phase 4 of drug development: - Answer✔️✔️-This phase is voluntary and
involves postmarket surveillance of the drug's therapeutic effects at the
completion of phase 3. The pharmaceutical company receives reports from
doctors and other health care professionals about the therapeutic results
and adverse effects of the drug. Some medications, for example, have been
found to be toxic and have been removed from the market after their initial
release.
Explain first pass metabolism - Answer✔️✔️-much of the drug is lost in the
absorption process. The liver metabolizes many drugs, thus reduces the
bioavailabilty of the drug.
What is the fasted route of absorption: - Answer✔️✔️-The fastest route of
absorption is inhalation, and not as mistakenly considered the IV
administration.
Why does the GI tract take longer to absorb? - Answer✔️✔️-The GI tract is
lined with epithelial cells; drugs must permeate through these cells in order
to be absorbed into the circulatory system.
What is One particular cellular barrier that may prevent absorption of a
given drug? - Answer✔️✔️-the cell membrane. Cell membranes are
essentially lipid bilayers which form a semipermeable membrane. Pure
lipid bilayers are generally permeable only to small and uncharged solutes,
hence whether or not a molecule is ionized will affect its absorption, since
ionic molecules are charged.
What is solubility? - Answer✔️✔️-Solubility favors charged species,
permeability favors neutral species. Some molecules have special exchange
proteins and channels to facilitate movement from the lumen into the
circulation.
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