UCF PCB3233 Exam 2 Immunology Weigel
Practice Questions and Answers
iCB3 is a ligand for - Answer️️ -CR3 and CR4 receptors on
macrophages
Scavenger receptors prefer negatively charged molecules such as -
Answer️️ -nucleic acids, phosphate containing lipoteichoic acis
(gram +) and LPS ...
UCF PCB3233 Exam 2 Immunology Weigel
Practice Questions and Answers
iCB3 is a ligand for - Answer✔️✔️-CR3 and CR4 receptors on
macrophages
Scavenger receptors prefer negatively charged molecules such as -
Answer✔️✔️-nucleic acids, phosphate containing lipoteichoic acis
(gram +) and LPS (gram -)
CR3 and CR4 can also recognize - Answer✔️✔️-LPS (gram -),
lipophosphoglycan (protozoa), filamentous hemagglutinin, cell
surface structures on yeast
Mannose receptors recognize - Answer✔️✔️-LPS (gram -), CPs and
ManLam of bacteria
When TLR's are engaged, what mechanism is engaged in the
macrophage? - Answer✔️✔️-A signal is sent to the nucleus to make
and secret inflammatory cytokines
What does TLR3 bind to? - Answer✔️✔️-RNA viruses
What does TLR4 bind to? - Answer✔️✔️-LPS (gram - bacteria)
What does TLR7 bind too? - Answer✔️✔️-Single strained RNA
What are the steps of the TLR4 signaling mechanism? - Answer✔️✔️-
Complex of TLR4, MD2, CD14 and LPS assembles on macrophage
surface > MyD88 binds TLR4 and activated IRAK4 to phosphorylate
TRAF6, which leads to phosphorylation and activation of IKK . IKK
phosphorylates IκB, leading to it's degradation and release of NFκB
which enters the nucleus and activates transpition of genes for
inflammatory cytokines which are synthesized in the cytoplasm and
secreted via the ER
What 5 genes are transcribed because of the TLR4 recognition? -
Answer✔️✔️-IL1, IL6, CXCL8, IL12 and TNFα
IL1, IL6, CXCL8, IL12 and TNFα are all considered to be what? -
Answer✔️✔️-Inflammatory cytokines
Describe neutrophils - Answer✔️✔️-Common myeloid precursor >
granulocyte/macrophage progenitor > neutrophil 40-75% of
leukocytes effectors of innate immunity, specializing in capture,
engulfment and killing of microbes, work in anaerobic conditions
found in damaged tissue, short lived, die at site of infection,
phagocytic cell that contain toxic substances in intracellular
granules, 60% of hematopoietic activity in the bone marrow, where
a large reserve is kept
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