What does folate deficiency resemble?
megaloblastic anemia as seen in B12 deficiency except that neurologic abnormalities are absent
When does megaloblastic anemia of folate deficiency develop?
within 4-5 months
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What does folate deficiency resemble? - ANSWER- megaloblastic anemia as seen
in B12 deficiency except that neurologic abnormalities are absent
When does megaloblastic anemia of folate deficiency develop? - ANSWER- within
4-5 months
When does neural tube closure take place? - ANSWER- 21-28 days post
conception
What is the most common neural tube defect? - ANSWER- spina bifida
What is the recommended daily intake of folic acid for nonpregnant women with
no known risk factors for neural tube defect? - ANSWER- 400 mcg
What medication places women at a higher risk for a neural tube defect-affected
pregnancy? - ANSWER- anticonvulsants
What ethnicity is at a higher risk for having babies with congenital neural
malformations? - ANSWER- hispanic
What antibiotics should be avoided in pregnancy? - ANSWER- tetracyclines,
fluoroquinolones, bactrim (in the 1st trimester), macrobid in the last few weeks of
pregnancy
What is 1st line therapy for treating UTI in pregnancy? - ANSWER- • Nitrofurantoin
monohydrate/macrocrystals 100 mg orally twice daily for 5-7
days or
• Amoxicillin 500 mg orally twice daily (alternative: 250 mg orally three times
daily) for 5-7 days or
, • Amoxicillin-clavulanate 500/125 mg orally twice daily for 3-7 days
(alternative: 250/125 mg orally three times daily for 5-7 days) or
• Cephalexin 500 mg orally twice daily for 3-7 days
What are risk factors for gestational diabetes? - ANSWER- obesity, older age,
having a family history of type 2 diabetes or belonging to an ethnic group at
increased risk for the condition (such as Hispanic, Native American, South or
East Asian, African American, or Pacific Islands descent)
Women with gestational diabetes are at higher risk for what? - ANSWER-
gestational htn, preeclampsia, c/s, and having diabetes later in life
The offspring of women with gestational diabetes are at increased risk for what? -
ANSWER- macrosomia, neonatal hypoglycemia,
hyperbilirubinemia, operative delivery, shoulder dystocia, and birth trauma
Describe ACOGs recommended 2 step approach to dx GD in pregnancy? When is
the test usually performed? - ANSWER- first screening with the administration of
50 g of an oral glucose solution followed by a 1-hour venous glucose
determination. Those women meeting or exceeding the screening threshold of >
or = 140 undergo a 100-g, 3-hour diagnostic oral glucose tolerance test (OGTT); at
24-28 weeks
In women in whom GD is diagnosed, what is the blood glucose cutoff?
(depending on community prevalence rates) - ANSWER- 135-140
What is the recommended initial management of women diagnosed with DM? -
ANSWER- nutritional counseling by a registered dietitian, if possible, and advice
on a moderate exercise
program.
When is postpartum screening of GD recommended? - ANSWER- 6-12 weeks
postpartum
What percentage of women experience some type of mood disturbance in the
postpartum period? - ANSWER- 85%
Some women may be abnormally sensitive to changes in the hormonal milieu and
may develop depressive symptoms when treated with what? - ANSWER-
exogenous estrogen and progesterone
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