,1. Which of the following factors most significantly affects the
pharmacokinetics of a drug in a patient with liver disease?
a) Age
b) Route of Administration
c) Protein Binding
d) Drug Half-Life
Answer: c) Protein Binding
Rationale: Liver disease affects albumin levels, which impact
drug distribution and binding.
, 3. Which class of drugs is considered first-line therapy for
managing hypertension in patients with diabetes?
a) Beta-blockers
b) ACE inhibitors
c) Calcium channel blockers
d) Thiazide diuretics
Answer: b) ACE inhibitors
Rationale: ACE inhibitors are protective for renal function in
diabetic patients and are often first-line.
### Fill-in-the-Blank Questions
4. The therapeutic range refers to the concentration of a drug in
the bloodstream that is effective without causing ________.
Answer: toxicity
Rationale: The therapeutic range is the interval between the
minimum effective concentration and the minimum toxic
concentration.
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