Samenvatting van het vak "Stowisseling & Hormonen 1" gegeven door prof. De Block in de 2e Bachelor Geneeskunde aan de UA. Volledige samenvatting gebaseerd op slides én lesnotities.
Bevat onder andere duidelijke overzichten van de hypothalamo-hypofysaire assen.
Fysiologie van het groeihormoon.............................................................................................................. 40
Synthese en secretie..........................................................................................................................40
Hypothalamo-hypofysaire-groeihormoon as...........................................................................40
Controle van GH-secretie....................................................................................................... 41
Werking van GH................................................................................................................................. 42
Fysiologische effecten............................................................................................................ 42
Pathologie.......................................................................................................................................... 43
GH-deficiëntie.........................................................................................................................43
GH-excess..............................................................................................................................43
Fysiologie van de hypothalame-hypofysaire gonadale as bij de man....................................................44
Anatomie............................................................................................................................................ 44
Hormonaal systeem........................................................................................................................... 45
GnRH en LH/FSH synthese................................................................................................... 45
Testes als eindorgaan.............................................................................................................46
Testosteron.........................................................................................................................................47
Biologische effecten van testosteron en dihydrotestosteron.................................................. 48
Fysiologie van de bijnier............................................................................................................................. 50
Morfologie...........................................................................................................................................50
Histologie................................................................................................................................50
Synthese van bijnierschorshormonen................................................................................................ 50
Synthese van cortisol............................................................................................................. 51
Synthese van aldosteron........................................................................................................ 52
Synthese van androgenen......................................................................................................52
Pathofysiologie....................................................................................................................... 52
Glucocorticoïden - cortisol..................................................................................................................53
Hypothalamo-hypofysaire-bijnier as....................................................................................... 53
Adrenocorticotroop hormoon (ACTH).....................................................................................54
Werking van glucocorticoïden................................................................................................ 54
Mineralocorticoïden - aldosteron........................................................................................................ 56
Controle van aldosteron......................................................................................................... 56
Werking van aldosteron.......................................................................................................... 56
Androgenen........................................................................................................................................56
Synthese van bijniermerghormonen...................................................................................................57
Biosynthese van catecholamines........................................................................................... 57
Werking van catecholamines..................................................................................................57
Metabolisatie van catecholamines..........................................................................................58
Pathofysiologie: hyperfunctie............................................................................................................. 58
2
Fysiologie van de schildklier...................................................................................................................... 62
Anatomie en histologie....................................................................................................................... 62
Synthese van iodothyronines............................................................................................................. 62
Biosynthese van iodothyronines.............................................................................................62
Transport van iodothyronines................................................................................................. 64
Transformatie van iodothyronines.......................................................................................... 64
Schildklierwerking...............................................................................................................................65
Hypothalamo-hypofysaire-schildklier as................................................................................. 65
Metabole activiteit van schildklierhormonen........................................................................... 66
Schildklierfunctie testen......................................................................................................................67
Pathologie: hyperthyroïdie..................................................................................................................67
Graves-Basedow.................................................................................................................... 68
Toxisch adenoom....................................................................................................................68
Toxische multinodulaire goiter................................................................................................ 68
Jodium-geïnduceerde hyperthyroïdie..................................................................................... 69
Thyroïditis............................................................................................................................... 69
Kliniek van hyperthyroïdie...................................................................................................... 70
Pathologie: hypothyroïdie...................................................................................................................70
Etiologie..................................................................................................................................71
Hashimoto = chronisch autoimmune thyroïditis......................................................................71
Kliniek van hypothyroïdie........................................................................................................72
Fysiologie van de bijschildklier.................................................................................................................. 73
Anatomie en histologie....................................................................................................................... 73
Synthese van parathyroïdhormoon (PTH)..........................................................................................73
Controle van PTH................................................................................................................... 73
Werking van parathyroïdhormoon (PTH)........................................................................................... 75
Werking van PTH in nieren.....................................................................................................75
Werking van PTH in bot..........................................................................................................76
Werking van PTH in darmen.................................................................................................. 77
Calcium metabolisme......................................................................................................................... 77
Calcium homeostase.............................................................................................................. 78
Fosfaat homeostase............................................................................................................... 79
1,25-dihydroxy-vitamine D3....................................................................................................79
Calcitonine..............................................................................................................................80
Fysiologie van het lipidenmetabolisme..................................................................................................... 81
Lipiden................................................................................................................................................81
Cholesterolmetabolisme......................................................................................................... 81
Lipoproteïnen..................................................................................................................................... 83
Lipoproteïnen..........................................................................................................................83
3
, Apolipoproteïnen.................................................................................................................... 83
Exogene en endogene pathway.........................................................................................................84
Exogene cholesterolpathway..................................................................................................85
Endogene cholesterolpathway............................................................................................... 85
Regulatie van LPL.................................................................................................................. 86
Regulatie van LDL-receptor....................................................................................................86
Implicaties voor de kliniek.................................................................................................................. 87
Bepaling van bloedlipiden.......................................................................................................87
Hyperlipidemie........................................................................................................................88
Werkingsmechanismen van lipiden-verlagende medicatie................................................................ 89
Cholesterolverlagende medicatie........................................................................................... 89
Triglyceriden verlagende medicatie........................................................................................ 91
Effecten van lipidenverlagende medicatie.............................................................................. 92
Gewichtshomeostase.................................................................................................................................. 93
Lichaamssamenstelling en metabolisme............................................................................................93
Antropometrische metingen....................................................................................................93
Metabolisme........................................................................................................................... 94
Centraal zenuwstelsel........................................................................................................................ 94
Hypothalamus.........................................................................................................................94
Melanocortine systeem...........................................................................................................95
Autonoom (perifeer) zenuwstelsel......................................................................................................95
Communicatie tussen vetcellen en hersenen.....................................................................................95
Leptine....................................................................................................................................95
Adiponectine...........................................................................................................................96
Communicatie tussen gastro-intestinaal stelsel en hersenen............................................................ 97
Ghreline.................................................................................................................................. 97
Glucagon-like peptide-1 (GLP-1)............................................................................................98
Oxyntomoduline......................................................................................................................99
Communicatie tussen pancreas en hersenen.................................................................................... 99
Insuline................................................................................................................................... 99
Amyline.................................................................................................................................100
Communicatie tussen smaakpapillen en hersenen..........................................................................100
Communicatie tussen lever en hersenen......................................................................................... 100
FGF-21................................................................................................................................. 100
Communicatie binnen de hersenen..................................................................................................101
Circadiaans ritme..................................................................................................................101
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller katovandenbroucke. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $17.50. You're not tied to anything after your purchase.
