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NR547 Week 5 exam fully solved (already passed)
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NR547 Week 5 exam fully solved (already passed)
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NR547 Week 5 examfully solved (already
passed)
Medications for depression - answer SSRIs
SNRIs
SDRIs
TCAs
MAOIs
SSRIs - answer -Action: inhibit 5-HT reuptake
-Examples: citalopram, escitalopram, fluoxetine, paroxetine, sertraline
-Adverse effects:
• nausea
• agitation
• diarrhea
• headache
• weight gain
• sexual side effects
SNRIs - answer -inhibit 5-HT reuptake
-inhibit NE reuptake (↑ energy, focus)
-increase DA in prefrontal cortex (↑ cognition)
-Examples: desvenlafaxine, duloxetine, levomilnacipran, venlafaxine
-Adverse effects:
• elevated blood pressure
,• nausea
• sweating
• tremors
• anxiety
• insomnia
• constipation
• anorexia
• sexual dysfunction
SDRIs - answer -inhibit DA reuptake (↑alertness, motivation)
-inhibit NE reuptake (↑energy)
-Adverse effects:
• agitation
• headache
• dry mouth
• constipation
• weight loss
TCAs - answer -Action: inhibits the reuptake of serotonin and
norepinephrine; blocks norepinephrine, histamine, and acetylcholine
receptors
-Examples: amitriptyline, clomipramine, desipramine, doxepin
-Common Side Effects:
• dry mouth
• constipation
• blurred vision
• urinary retention
• sedation
• weight gain
• hypotension
, • tachycardia
• sexual dysfunction
MAOIs - answer -Action: increases norepinephrine and serotonin by
inhibiting the enzyme that inactivates it
-Examples: isocarboxazid, phenelzine, tranylcypromine
-Common Side Effects:
• sedation
• dizziness
• sexual dysfunction
• hypertensive crisis
Prescribing pearls: citalopram (Celexa) - answer mild antihistamine effects
Prescribing pearls: escitalopram (Lexapro) - answer no known drug
interactions
Prescribing pearls: fluoxetine (Prozac) - answer longest half-life
Prescribing pearls: paroxetine (Paxil) - answer also treats social anxiety
and insomnia
Prescribing pearls: fluvoxamine (Luvox) - answer treats anxious
depression smokers require increased dose
Prescribing pearls: sertraline (Zoloft) - answer also treats social anxiety
and hypersomnolence
Prescribing pearls: bupropion (Wellbutrin) - answer NDRI may improve
energy, alertness, and motivation; not first line treatment for anxiety;
contraindicated in clients with a history of seizures
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