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PMY 302 Block 1 Questions with 100 % correct Answers | Verified | A+

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  • PMY 302 Block 1
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  • PMY 302 Block 1

how do agonists binding to receptors alter cellular processes and cha/nge cellular phenotype - alter expression level of protein and the turnover number of the enzyme stereospecificity - most drugs are asymmetric (chiral or optically active); one stereoisomers binds with much greater affinity to...

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  • September 1, 2024
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  • Exam (elaborations)
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  • PMY 302 Block 1
  • PMY 302 Block 1
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PatrickKaylian
PMY 302 Block 1

how do agonists binding to receptors alter cellular processes and cha/nge cellular phenotype -
alter expression level of protein and the turnover number of the enzyme




stereospecificity - most drugs are asymmetric (chiral or optically active); one stereoisomers binds
with much greater affinity to the specific receptor



pharmacology - study of all compounds that interact with the body



pharmacodynamics - what a drug does to the body. Includes the molecular mechanisms by which
a drug acts



pharmacokinetics - what the body does to a drug. Usually depends on the concentration at the
site of action



pharmacogenetics - responses to a drug as a consequence of genetic differences between
individuals



EC50 - Half maximal effective concentration. induces a response halfway between the baseline
and maximum after a specified exposure time. It is commonly used as a measure of drug's potency.



LD 50 - amount of an ingested substance that kills 50 percent of a test sample



phase 1 of biotransformation - makes drug slightly less hydrophobic



phase 2 of biotransformation - makes drug very hydrophillic

, drug - any agent that affects the living process, including chemicals that mimic or antagonize
endogenous



dose - amount of medication administered at single time (effects toxicity)



response - effect of a drug on the body, including both intended and unintended effects



therapeutic response - the desired effect



adverse effect - side effects



toxic response - any harmful repsonse



idiosyncratic response - individual hypersensitivity; happens on first dose



atropa belladona - dilates pupils

important that drug came from plant



Law of Mass Action - D + R <-- --> DR;

increasing the amount drug will cause greater amounts of drug receptor complexes to formed

the DR complex exerts the therapeutic response



saturability - a limited amount of receptors mediate the actions of a drug



reversbility - drugs bind to but then dissociate from their specific receptor




Agonist - a drug that binds to a receptor and mimics the effect of the endogenous ligand

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