UNE BIOCHEMISTRY FINAL, FINAL, FINAL
EXAM REVIEW UNE MEDICAL
BIOCHEMISTRY
A 47-year-old male is prescribed a statin (HMG-CoA reductase inhibitor) to
manage his elevated LDL cholesterol. What is the initial mechanism of action for
obtaining the desired effect in this man? - ANSWERS-Decreasing hepatic
cholesterol biosynthesis
A deficiency in the LDL receptor will result in an initial decrease in which of the
following? - ANSWERS-Intracellular cholesterol
A 45-year-old man has a mild heart attack and a history of vascular disease. He is
placed on a Mediterranean diet and statin drug therapy. Which of the following
will be the most likely result of this drug therapy? - ANSWERS-Low blood LDLs
A 45-year-old man is found to have an elevated serum triglycerides of >
730mg/dL. He tells you he forgot to fast before his visit and he ate a full breakfast
of bacon and eggs before the labs were drawn. Which of the following
lipoproteins would be the largest contributors to a measurement of plasma
triglycerides in this situation? - ANSWERS-Chylomicrons and VLDLs
A comatose infant is brought to the ER. In the course of the examination, plasma
ammonia was found to be elevated 20-fold over normal values. Urine orotic acid
,and uracil were both greater than normal. A defect of which of the following
enzymes is the most likely diagnosis? - ANSWERS-Ornithine transcarbamoylase
Your patient presents with a deficiency of the enzyme that catalyzes synthesis of
N-acetylglutamate (NAGs). Which of the following would be a consequence of this
deficiency in the patient? - ANSWERS-Increased amino acids in the blood
The cellular uptake of LDL increases intracellular cholesterol levels. This has which
of the following impacts on de novo cholesterol synthesis? - ANSWERS-Increases
degradation of HMG-CoA reductase
Dietary cholesterol is primarily transported in the body by which of the following
lipoproteins? - ANSWERS-Chylomicron
Secondary bile salts are generated by bacterial modification of primary bile salts
in the intestinal lumen. These modifications have which of the following impacts
on bile salt solubility? - ANSWERS-Decrease solubility
In the reaction catalyzed by cholesterol ester transfer protein (CETP), the VLDL
particle receives which of the following compounds from HDL particles? -
ANSWERS-Cholesterol-ester
In reverse cholesterol transport HDL interacts with the ABCA1 transporter to
move cholesterol from the cell to the HDL. This also requires the activity of which
of the following enzyme? - ANSWERS-Lecithin cholesterol acyltransferase (LCAT)
,HDL particles interact with VLDL particles to exchange cholesterol ester for
triacylglyerols. Which of the following enzymes is responsible for this process? -
ANSWERS-Cholesterol ester transfer protein (CETP)
Which of the following is a major source of extracellular cholesterol for human
tissues? - ANSWERS-LDLs
An individual is suspected of having a deficiency in branched chain keto acid
dehydrogenase. Supplementation of which of the following vitamins or cofactors
may help resolve this issue? - ANSWERS-Thiamine
A 55-year old man presents to his primary care physician with bouts of dizziness
and confusion. He is diagnosed with hyperhomocysteinemia due to a deficiency of
cystathionine-ß synthase. In this individual which of the following amino acids
could potentially become essential? - ANSWERS-Cysteine
Phenylketonuria can be caused by an enzymatic deficiency or it can present due
to a deficiency in which of the following required metabolic cofactors? -
ANSWERS-Tetrahydrobiopterin (BH4)
A 17-year old female presents to her primary care and is diagnosed with a Vitamin
B12 (cobalamin) deficiency. In this individual, which of the following reactions
would be compromised? - ANSWERS-Conversion of methyl malonyl-Co A to
succinyl-CoA
, A 15-year-old female presents to her pediatrician with concerns over her inability
to sleep, increased feelings of depression and generalized fatigue. A full
laboratory work-up is ordered and based on these findings she is diagnosed with a
melatonin deficiency. Based on this information, metabolism of which of the
following amino acids is likely impaired? - ANSWERS-Tryptophan
A 52-year- old male sought medical help complaining about progressive
appearance of hyperchromic (hyper pigmented) papules on the edge of the
second finger of both hands. He also complained about darkening of urine.
Incisional biopsy of one of the spots on his hands and urine sample tested positive
for or homogentisic acid. Based on these findings a diagnosis of alkaptonuria is
made. This diagnosis is consistent with a deficiency in which of the following
enzymes? - ANSWERS-Homogentisate oxidase
Methotrexate is a potent anticancer agent that starves dividing cells of
deoxyribonucleotides through direct inhibition of which of the following
processes? - ANSWERS-Metabolism of folic acid
A 47-year-old man complains of pain in the joints of his left big toe, which are
obviously swollen and tender. The pain has been chronic but became intolerable
the day after Thanksgiving when he had a large meal and several glasses of red
wine. Based on this information a diagnosis of gout is made. Which of the
following is involved in the pathophysiology of this patient's condition? -
ANSWERS-Elevated uric acid
Which of the following is the common intermediate for purine synthesis? -
ANSWERS-Inosine monophosphate
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