The highest point in a reaction coordinate diagram represents _____. - ANSWER-the transition state
Of the following ions, which would be most likely to participate in metal ion catalysis? - ANSWER-Zn2+
An organic molecule that is tightly bound to an enzyme and participates in an enzyme catalyzed ...
BCHM 307 Exam Questions| Already
Answered| GRADED A+
The highest point in a reaction coordinate diagram represents _____. - ANSWER-the transition state
Of the following ions, which would be most likely to participate in metal ion catalysis? - ANSWER-Zn2+
An organic molecule that is tightly bound to an enzyme and participates in an enzyme catalyzed reaction
is specifically referred to as a _____. - ANSWER-prosthetic group
Which of the following amino acids would be most likely found in the active site of an enzyme that uses
acid-base catalysis? - ANSWER-His
The ability for an enzyme to pick out one particular substrate from the myriad of molecules floating
around its environment is an example of _____. - ANSWER-specificity
How does a catalyst affect the overall deltaG of an endergonic reaction? - ANSWER-it has no effect
Which of the following is the most effective way to increase the rate of a biochemical reaction? -
ANSWER-add a catalyst
What amino acid performs the nucleophilic attack during the chymotrypsin mechanism? - ANSWER-Ser
How does a catalyst increase the rate of a reaction? - ANSWER-it allows reacting molecules to more
easily form the transition state
Of all the species that enzymes bind, they are thought to bind most tightly to _____. - ANSWER-
transition states
Chymotrypsin catalyzes the hydrolysis of a peptide bond and is therefore categorized as a _____. -
ANSWER-hydrolase
, During the first half of the chymotrypsin mechanism where the acyl-enzyme intermediate is formed,
what role does His play? - ANSWER-general base then general acid
Chymotrypsin has a large specificity pocket to bind the aromatic amino acids while elastase has a very
small specificity pocket meant to bind Ala or Gly. Which of the following amino acid substitutions
changes the specificity pocket of chymotrypsin to that of elastase? (Try to figure this out based on
amino acid structures rather than just looking it up!) - ANSWER-Gly -> Val
If the Asp in the chymotrypsin active site was mutated to another amino acid, which of the following
would be considered an invisible mutation in that it is least likely to impact the function of the enzyme?
- ANSWER-Asp → Glu
Zymogens are not enzymatically active because _____. - ANSWER-their active sites are distorted and
incapable of enzymatic activity
The molecule chymotrypsinogen is known as a(n) _____. - ANSWER-zymogen
What three amino acids are found in the catalytic triad of chymotrypsin? - ANSWER-Asp, His, Ser
Conversion of factor X to factor Xa represents a(n) _____ form of activation; binding of antithrombin to
thrombin represents a(n) _____ form of inhibition. - ANSWER-irreversible; reversible
An enzyme that forms a covalent bond with its substrate during the course of a reaction is considered to
undergo _____. - ANSWER-covalent catalysis
Which protein in the blood is responsible for converting fibrinogen to fibrin? - ANSWER-thrombin
Different enzymes that catalyze the same reaction are known as _____. - ANSWER-isoenzymes
In an enzyme mechanism that generates a negative charge in the transition state, which of the following
would be most effective to have in the active site of the enzyme? - ANSWER-transition metal cation
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