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Immunology & Serology Review for BOC Prep Exam Questions And Correct Answers.
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Characteristics of Immunogens (Antigens) that affect Immunogenicity - Answer 1. Large molecule (at least 10 KDa) 2. High complexity (simple repeating units don't make good immunogens) 3. Chemical composition (proteins and polysachs. are better than carbs, lipids & nucleic acids) 4. Foreignnes...

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  • September 4, 2024
  • 11
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

Subjects

  • characteristics of immunogens

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  • Boc serology immunology
  • Boc serology immunology

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Immunology & Serology Review for BOC
Prep Exam Questions And Correct
Answers.
Characteristics of Immunogens (Antigens) that affect Immunogenicity - Answer 1. Large molecule (at
least 10 KDa)

2. High complexity (simple repeating units don't make good immunogens)

3. Chemical composition (proteins and polysachs. are better than carbs, lipids & nucleic acids)

4. Foreignness (the more different from host, the more immunogenic)



Differentiate Active from Passive Immunity - Answer *Active:* Individual produces antibody. Follows
immunization or infection. Lasting.

*Passive:* Antibody transferred to individual. No memory, temporary.



What type of immunity is associated with rubella immunization? - Answer Active immunity



What type of immunity is associated with neonatal (<4 months), syphilitic IgG antibody titers? - Answer
Passive immunity



Differentiate Natural from Adaptive Immunity - Answer *Natural:* Innate, non-specific, no memory
(e.g. skin, phagocytosis, natural killer cells, stomach acid)

*Adaptive:* Acquired, specific, memory (T cells - cytokines & B cells - antibodies)



Differentiate between the adaptive immunities: Cellular and Humoral - Answer *Cellular:* T
cells/Lymphokines, primary defense against viral/fungal infections; delayed hypersensitivity.

*Humoral:* B cells (plasma cell)/Antibody, primary defense against bacterial infections, antibody
dependent cellular cytotoxicity (ADCC).



Characteristics of IgG - Answer 1. greatest concentration in serum

, 2. 4 subclasses

3. activates complement

4. crosses placenta

5. 75% of total antibody concentration



Characteristics of IgM - Answer 1. largest antibody in body

2. fixes complement best

3. prominent in early immune response (indicated acute infection)

4. 5-10% of antibody concentration



Characteristics of IgA - Answer 1. predominant Ab in secretions (tears, saliva)

2. 2 subclasses: Serum IgA (monomer) & secretory IgA (dimer)

3. primary defense against some local infections at mucosal surface



Characteristics of IgD - Answer 1. unknown function

2. present on B cell surface



Characteristics of IgE - Answer 1. allergy

2. triggers release of histamine from mast cells



To remember Antibody Functions:

GMADE - Answer G: Greatest concentration, Goes across placenta

M: Mega (largest), activates complement

A: sAliva, teArs

D: Don't know function

E: allergEE (allergy)



Be familiar with the Immune Response Curve (graph) - Answer IgM is greatest in 1st exposure
(sensitizing dose)

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