NUR 242 EXAM #2 QUESTIONS WITH COMPLETE SOLUTIONS

NUR 242 EXAM ONE QUESTIONS WITH
COMPLETE SOLUTIONS


Whatdisdpharmacology?d-dastudydofddrugsdthatdalterdfunctionsdofdlivingdorganisms

whatdisdpharmacokinetics?d-
dathedstudydofdhowdtheddrugsdmovedwithindthedbodydtodreachdsitesdofdaction,dmetabolism,da

nddexcretion

Whatdisdabsorption?d-
dathedprocessdthatdoccursdfromdthedtimedtheddrugdentersdthedbloodstream. dOnsetdofddrugdac

tiondisddetermineddbydrate.

Whatdfactorsdaffectdratedanddextentdofddrugdabsorption?dSATAd-dadosage,dform,droute
admindsitedblooddflow,dGIdfunctiond
presencedofdfood,dotherddrugs

Whatdisddistribution?d-datransportdofddrugsdindthedbody

Whatdcarriesddrugsdanddwheredto?d-
dablooddanddtissuedfluidsdtodactiondsites,dmetabolismdsites,dexcretiondsites




Whatdaffectsddistribution?d-daproteindbinding:ddrugsdbinddtodactdasdcarriers
blood-braindbarrier:dextremelydsmalldtodcross
pregnancyd-dplacenta
lactationd-dmanyddrugsdenterdthedbreastdmilk

whatdisdmetabolism?d-dathedwaydtheddrugsdaredinactivateddbydthedbodyd(cytochromedP-
450denzymedpathway)

whatdareddrugsdchangeddtodwhendmetabolized?d-dainactivedmetabolites
activedmetabolites
proddrugsd-ddrugsdthatdaredinactiveduntildmetabolized

wheredareddrugdmetabolizingdenzymesdlocatedd-
dakidney,dliver,dRBCs,dplasma,dlungs,dGIdmucosa

, Whatdaredfactorsdthatdaffectdmetabolism?d-daenzymedinductiond-
dchronicdadministrationdpromotesdthedliverdtodproducedlargerdamountsdofdthedenzymedandda

cceleratesdmetabolism
enzymedinhibitiondthatdoccursdwhendtwoddrugsdaredbeingdgivendatdthedsamedtimedthatdutiliz
edthedsamedenzyme

whatdisdexcretind-daeliminationdfromdthedbody

whatdisdthedmargindofdsafetydfordaddrug?d-datherapeuticdindexdofdtheddrug

whatdisdrequireddfordexcretion?d-
daadequatedfunctiondofdthedcirculatorydsystem,dkidneysdbowel,dlungs,danddskin




whatdisdpolypharmacy?d-
datakingdmultipleddrugs;dputsdindividualsdatdriskdforddrugdinteractions




whatddoesditdmakedsomeonedmoredsusceptibledtodifdthey'red85dwithdkidneydproblems?d-
dadrugdtoxicity




whatdisdaddrugsd"halfdlife"d-
dathedtimeditdtakesdfodhalfdofdtheddrugdtodbedeliminateddfromdthedbody




whatdisdthedorder/sequencedofdpharmacokinetics?d-
daabsorption,ddistribution, dmetabolism,dexcretion




whatdorganddoesdadlotdofdmetabolizing?d-dakidney

whatdisdadscheduledIddrug?d-
dahasdnodacceptabledmedicalduse,dhighdpotentialdfordabused(i.e.dheroine,dLSD)




whatdisdadscheduledIIddrug?d-
danarcoticsdordstimulants dwithdhighdpotentialdfordabused(oxycodone,dmorphine,dadderall)




whatdisdadscheduledIIIddrug?d-
dalessdpotentialdfordabused(Tylenoldwithdcodeine,danabolicdsteroids)




whatdisdadscheduledIVddrug?d-dahasdlowerdpotentialdfordabused(versed,dXanax)

whatdisdadscheduledVddrug?d-dapreparationsdthatdhavedlimiteddquantitiesdofdnarcotics

whatdisdsynergism?d-
datwoddrugsdwithddifferentdactionsdcreatedadgreaterdeffectd(i.e.dacetaminophend+dopioids)




Whatdaredthedpatient-relateddvariables?dSATAd-daage,dbodydweight
genetics,dethnicity,dgender
pharmacogeneticsd(studydofdgeneticddrugdresponse)