UF M.S. MEDICAL PHYSIOLOGY AND PHARMACOLOGY EXAM |SOLVED!!
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Course
UF M.S. Medical Physiology and Pharmacology
Institution
UF M.S. Medical Physiology And Pharmacology
Understand the mechanism of spironolactone. - ACCURATE ANSWERS Aldosterone antagonist, prevents Na+ retention in CD. Increase K+ plasma conc,
Used in hyperaldosteronism, increased risk of hyperkalemia with antihypertension drugs
Understand the different methods for indentifying lead compounds....
UF M.S. MEDICAL PHYSIOLOGY
AND PHARMACOLOGY EXAM |
SOLVED!!
Understand the mechanism of spironolactone. - ACCURATE
ANSWERS✔✔ Aldosterone antagonist, prevents Na+ retention in CD.
Increase K+ plasma conc,
Used in hyperaldosteronism, increased risk of hyperkalemia with
antihypertension drugs
Understand the different methods for indentifying lead compounds. -
ACCURATE ANSWERS✔✔ Lead compounds are from natural
products, chemical banks, or rational drug design. Molecular docking
used to design the drug
Understand the classification of controlled substances. - ACCURATE
ANSWERS✔✔ Schedule I - (HIGH) (no medical use) Heroin, LSD,
Weed
Schedule II - (HIGH) (written rx, no refill) Morphine, amphetamine,
high dose Codeine
Schedule III - (MODERATE) (5 refill, 6 month) Ketamine, low dose
codeine
Schedule IV - (LOW) (5 refill, 6 month) Benzodiazepines
Schedule V - (LOWEST) (not typically abused) Diphenoxylate
,Understand the fundamentals of T0-T4 translational research. -
ACCURATE ANSWERS✔✔ T0 - (BASIC RESEARCH) Knowledge
about defining mechanisms, targets or lead molecules
T1 - (TRANSLATION TO HUMANS) Methods of Dx, Tx, Prevention
(phase 1)
T2 - (TRANSLATION TO PATIENTS) Efficacy of interventions in
optimal settings (Phase 2 & 3)
T3 - (TRANSLATION TO PRACTICE) How interventions work in real
world application (Phase 4)
T4 - (TRANSLATION TO COMMUNITY) Research results in
improved global health
Understand classes of medical devices. - ACCURATE ANSWERS✔✔
Class I - least reg.: Bandaid, exam gloves
Class II - Gen. control w/ special controls: Acupuncture neddles,
powered wheelchair, infusion pump, surgical drapes
Class III - Above + req. pre-market approval Support or sustain life:
pacemaker, defibrillators
Understand the data collected in phase I trials. - ACCURATE
ANSWERS✔✔ Maximum-tolerated dose/minimum dose for full target
engagement
ADME: Absorption, Distribution, Metabolism, Excretion
Toxicity
Adverse rxns
, Understand types of preclinical cancer models. - ACCURATE
ANSWERS✔✔ Ectopic xenograft
-ectopic implantation of cell/tissue (s.c., i.v., i.p.)
Orthotopic models
-implantation of cell line into organ of origin
Germ-line and conditional transgenic
-spontaneous or autochthonous development
Primary human tumor graft (PDX:patient-derived xenograft)
- direct implantation of freshly excised tumor
Carcinogen/tumor promotor
-development in response to carcinogen/tumor
promoting agent
Understand the purpose and intent of phase 0 clinical trials. -
ACCURATE ANSWERS✔✔ Provide a yes/no decision early in drug
dev.
Few, small doses
Understand the objectives and characteristics of phase II clinical trials. -
ACCURATE ANSWERS✔✔ Prelim data on efficacy and further safety
Small # subjects
Short duration
Short-term safety
Small PT population
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