Summary
Gespecialiseerde Farmacologie samenvatting
- Course
- Institution
Samenvatting Gespecialiseerde Farmacologie in tabellen: soort - functie fysiologisch - effect - bijwerkingen - voorbeelden
[Show more]
Seller
Follow
Studente11
Content preview
1. Endocrien systeem1.1 Antidiabetische geneesmiddelen
Groep Ftie in kort Voorbeelden Gebruik bij
Insuline Gluc uit bloed halen / Type I
Metformine ↑ gevoeligheid voor insuline in perifeer / Type II >>>
Hypoglycemische Stimulatie β-cellen -> ↑ insuline Glibenclamide (Daonil)
sulfonamides
Glinides Stimulatie β-cellen -> ↑ insuline (sneller in en uit) Repaglinide (Novonorm) Type II
Glitazones Genexpressie -> verbeteren ftie vetweefsel en ↓ insulineresistentie Pioglitazone (Acetos) Type II
Incretine mimetica/ Stimulatie β-cellen -> ↑ insuline Semaglutide (Ozempic, Wegovy, Rybelsus) Type II
GLP-1 agonisten Stimulatie α-cellen -> ↓ glucagon
Vertraagde maaglediging
Hypothalamus -> minder honger
DPP-4-inhibitoren / Inhibitie DPP-4 -> ↓ afbraak GLP / Type II
gliptines -> Stimulatie β- (↑ insuline) en α-cellen (↓ glucagon), vertraagde maaglediging
SGLT2 inhibitoren / Inhibitie glucosetransporter -> ↑ glucose uitplassen -> ↓ glucose in circulatie Empagliflozine, canagliflozine Type II
gliflozines
Glucagon Afbraak glycogeen + ↑ gluconeogenese Glucagen (SC) Hypoglycemie
, 1.2 Obesitas
Groep Ftie in kort Voorbeelden
GLP-1 agonisten Stimulatie β-cellen -> ↑ insuline Semaglutide (Ozempic, Wegovy, Rybelsus)
Stimulatie α-cellen -> ↓ glucagon
Vertraagde maaglediging
Hypothalamus -> minder honger
GLP-1/GIP dual incretine mimetica OO GLP-1 en GIP receptoren Tirzepatide
-> Stimulatie β- (↑ insuline) en α-cellen (↓ glucagon), vertraagde maaglediging (Mounjaro -> diabetes)(Zepbound -> obesitas)
GLP-1/glucagon dual receptor OO GLP-1 en glucagon receptoren /
agonisten -> ↑ ftie mitochrondria -> ↑ verbranding vet
-> ↓ leververvetting en inflammatie
-> glycogenolyse en hyperglycemie -> nood aan comb met GLP-1 agonist
Amyline ↓ hongergevoel
Fibroblast groeifactor 21 ↓ inname voedsel, ↑ oxidatie vetzuren en gezond vet
1.3 Thyroid
Groep Ftie in kort Voorbeelden Indicaties
Thyroid hormonen No groei, werking en O2 verdeling in weefsels Levothyroxine (Tetraiodothyronine, T4) Hypothyroïdie (OO antithyroide
No ontwikkeling CZS en verhoogde exciteerbaarheid neuronen medicatie)
Pos ionotroop en chronotroop effect op hart
Thyrostatische gm’en ↓ iodinatie, koppeling en perifere omzetting T4->> T3 Propylthiouracil Hyperthyroidie (OO β-blokkers en later
Antilich tegen TSH -> ↓ stimulatie thyroid thyroidhormonen)
Iodide ↓ iodinatie en secretie thyroidhormonen (directe werking) / Thyrotoxische crisis (thyroid storm)
Voorbereiding chirurgie
Desinfectatie OK
Nucleair accident
Radioactief iodine
1.4 Corticosteroïden
Groep Ftie in kort Voorbeelden Indicaties
Cortisol
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Studente11. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $17.79. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
73091 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now