Summary
Biochemie gastro-intestinaal stelsel samenvatting
- Course
- Institution
Samenvatting van Biochemie Gastro-Intestinaal stelsel
[Show more]
Seller
Follow
Studente11
Content preview
GI-stelsel – Biochemie1. Hormonen: thyroïd-, steroïd en (poly)peptide
hormonen
1.1 Inleiding
Eigenschappen
o Beïnvloeden fties op andere plaatsen in lichaam
o Organische stof
o Lage hoveelheden
Endocriene – paracriene – autocriene signalisatie
o Endocrien: doelwitcel = veraf gelegen
Stabiele hormonen, mag niet snel afgebroken w
Sterke verdunning in bloedbaan -> nood aan hoge affiniteit voor receptor
o Paracrien: doelwitcel ligt in onmiddelijke omgeving
Onstabiel, mag niet ver geraken -> snelle afbraak
Niet verdund -> hoge concnetratie in synaps -> lage affiniteit voor receptor
Bij lekkage in omgeving, te weinig affiniteit voor OO naburige cel
o Autocrien: secreterende cel = doelwitcel
Receptoren in
o Plasmamembraan
o Cytoplasma (diffusie door celmembraan)
Vb : cortisolR, bij OO cortisol ->> nucleus en w nucleaire receptor
o Celkern
Vb: thyroïdhormoonR
1.2 Affiniteit van de hormonen
H + R <-> HR
[ HR ]
Associatiecte: KA =
[ H ]∗[ R]
o No : grote waarde
1
o Eenheid :
M
o Sterkte van hormoon-receptorbinding
1
Dissociatiecte : KD =
KA
o No : kleine waarde
o = [H] bij 50% receptorbezetting (als [HR] = [R])
o Hyperbolische curve
o Hoe hoger concentratie vrij hormoon -> hoe hoger teceptorbinding
K∗[ H ]
Fractionele receptorbezetting =
( Ka∗[ H ] ) +1
o Hoeveel % vd receptor is bezet met hormoon
Scatchard Plot:
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Studente11. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $6.43. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
73918 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now