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CMN 568 Exam 3 - TB #1; Questions with Verified Answers 100% Correct
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CMN 568 Exam 3 - TB #1; Questions with VerifiedAnswers 100% Correct
Treatment for LTBI purpose CORRECT ANS-- Essential to controlling and eliminating TB
disease
- Reduces risk of LTBI to TB disease progression
- Use targeted testing to find persons at high risk for TB who would benefit from LTBI
treatment
- Several treatment regimens available
LTBI TX meds CORRECT ANS-- Isoniazid (INH)
- INH-rifapentine (RPT)
- Rifampin (RIF)
Isoniazid (INH) 9 month regimen CORRECT ANS-- Preferred
- 270 doses within 12 months
- Effective for HIV-infected as well as HIV-uninfected persons
- Can be given twice weekly via DOT (76 doses within 12 months)
- Preferred for children 2-11 years of age
, CMN 568 Exam 3 - TB #1; Questions with Verified
Answers 100% Correct
Isoniazid (INH) 6 month regimen CORRECT ANS-- Generally acceptable
- 180 doses within 9 months
- Can be given twice weekly via DOT (52 doses within 9 months)
- Shorter regimen not recommended for children, immunosuppressed persons, persons
whose x-rays suggest previous TB
Adverse Reactions to INH CORRECT ANS-- Peripheral neuropathy (give vitamin B6 if patient
has risk factors, or if s/s develop)
- Fetal hepatitis (pregnant/postpartum women at increased risk; monitor closely)
- Elevated liver enzymes (discontinue if liver enzyme levels exceed 3x normal with symptoms,
or 5x upper limit of normal with no symptoms.Closely monitor if signs/symptoms of liver
injury)
INH-rifapentine (RPT) CORRECT ANS-- 3 month duration usually
- Given in 12 once-weekly doses under DOT
- Offers equal option to 9 months daily INH, but does not replace other treatment options for
LTBI
, CMN 568 Exam 3 - TB #1; Questions with Verified
Answers 100% Correct
-Recommended for treating LTBI in other wise healthy people
- >12 years of age who had recent contact with infectious TB, or who had a tuberculin skin test
conversion or a positive blood test for TB infection
-Can be considered for specific groups that would benefit (e.g., need to complete treatment in
short time)
Rifampin (RIF) CORRECT ANS-- Alternative to INH is 4 months daily
- 120 doses within six months
- Should not be used in HIV-infected persons being treated with some ART
LBTI Treatment for Pregnancy and Breast Feeding CORRECT ANS-- 9 months of INH daily or
twice weekly; give with vitamin b6
- If cannot take INH, consult with TB expert
- 12-dose INH-RPT regimen not recommended for
pregnant women; its safety in pregnancy is not known
- Women at high risk for progression to TB disease,
especially HIV-infected or diabetic, should not delay LTBI treatment; monitor carefully
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