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Katzung's Basic and Clinical Pharmacology
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Test Bank- Katzung's Basic and Clinical Pharmacology, 16th Edition (Todd W. Vanderah, 2023) Latest Edition || All Chapters
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TEST BANK For Katzung's Basic and Clinical Pharmacology,16th Edition By {Todd W. Vanderah, 2024,} Verified Chapters 1
- 66, Complete Newest Version
Treatment of superficial fungal infections caused by dermatophytic fungi may be
accomplished with the use of? - ANSWER: 1. topical antifungal agent
2. oral antifungal agent
Examples of Topical Antifungal Agents - ANSWER: clotrimazole, efinaconazole,
econazole, ketoconazole, luliconazole, miconazole, oxiconazole, sertaconazole,
sulconazole, ciclopirox olamine, naftifine, terbinafine, butenafine, and tolnaftate
Examples of Oral Antifungal Agents - ANSWER: griseofulvin, terbinafine, fluconazole,
and itraconazole
(AZOLE DERIVATIVES) Topical imidazoles are: - ANSWER: clotrimazole, econazole,
ketoconazole, luliconazole, miconazole, oxiconazole, sertaconazole, and sulconazole
Topical imidazole coverage - ANSWER: wide range of activity against:
Dermatophytes (Epidermophyton, Microsporum, and Trichophyton)
and
Yeasts, including Candida albicans and Pityrosporum orbiculare
Topical imidazole coverage - ANSWER: Dermatophytes and yeasts
Topical imidazoles used in vulvovaginal candidiasis? - ANSWER: Miconazole and
Clotrimazole
available as a cream or lotion and as vaginal cream or suppositories - ANSWER:
Miconazole
available as a cream or lotion and as vaginal cream and tablets - ANSWER:
Clotrimazole
treatment of onychomycosis of the toenails - ANSWER: Efinaconazole (EFIctive for
onychomycosis)
How long is the medication for onychomycosis using Eficonazole? - ANSWER: 48
weeks
available as a cream and lotion for topical use - ANSWER: Econazole and Oxiconazole
, available as a cream for topical treatment of dermatophytosis and candidiasis and as
a shampoo or foam for the treatment of seborrheic dermatitis. - ANSWER:
Ketoconazole
treats dermatophytosis, candidiasis and seborrheic dermatitis? - ANSWER:
Ketoconazole
available as a cream - ANSWER: Luliconazole and Sertaconazole
available as a cream or solution - ANSWER: SULConazole (SULotion & Cream)
Why are topical antifungal-corticosteroid fixed combinations have been introduced?
- ANSWER: to provide more rapid symptomatic improvement than an antifungal
agent alone.
2 is better than 1.
Example of topical antifungal-corticosteroid fixed combination? - ANSWER:
Clotrimazole-betamethasone
How frequent do you need to apply certain topical antifungals to clear specific fungal
infections? - ANSWER: 1x- or 2x-daily : clears superficial dermatophyte (for 2-3 wks
using any of antifungals)
2x daily : clears seborrheic dermatitis (w/ ketoconzaole)
3x or 4x daily : clears paronychial and intertriginous candidiasis
AE of topical imidazoles? - ANSWER: stinging, pruritus, erythema, and local irritation.
Allergic contact dermatitis is uncommon.
This is a synthetic broad-spectrum antimycotic agent - ANSWER: Ciclopirox olamine
Coverage of Ciclopirox olamine? - ANSWER: activity against dermatophytes, Candida
species, and P orbiculare.
MOA of Ciclopirox olamine? - ANSWER: inhibits the uptake of precursors of
macromolecular synthesis
Site of action of Ciclopirox olamine? - ANSWER: probably the fungal cell membrane.
treatment of dermatomycosis, candidiasis, and tinea versicolor - ANSWER: Ciclopirox
olamine (1% cream)
treatment of mild to moderate onychomycosis of fingernails and toenails? -
ANSWER: Ciclopirox olamine (8% cream)
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