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PHCY 402- Tetracyclines Exam Latest Update

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PHCY 402- Tetracyclines Exam Latest Update ...

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  • September 7, 2024
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  • PHCY 402- Tetracyclines
  • PHCY 402- Tetracyclines
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PHCY 402- Tetracyclines Exam
Latest Update

Tetracyclines are used against broad Gram +/- _____ - Answer parasites

Tetracyclines are (static/cidal) - Answer static

Tetracycline structures are made up of ____ rings - Answer four

Tetracyclines (reversibly/irreversibly) binds the the __ site of the ____ ribosome - Answer
reversibly; A; 30S

T/F: tetracyclines are the only drugs that bind 30S subunit - Answer false
(aminoglycosides also)

Tetracycline prefer which type of environment: acidic, basic, or neutral? - Answer acidic

Tetracyclines can undergo a process called ____ where they bind with metal cations and
become inactive - Answer chelation

two ways tetracyclines would get into G+ - Answer passive diffusion & active transport

How do hydrophilic tetracyclines get into G- - Answer pores

How do lipophilic tetracyclines get into G- - Answer diffuse through membrane

resistance that causes tetracycline to be dislodged from its binding site - Answer Tet(O)

major resistance associated with tetracyclines - Answer efflux

T/F: tetracyclines can be given to pregnant women - Answer false (crosses the placenta;
also excreted in breast milk)

tetracyclines have (good/bad) CNS penetration - Answer bad (would NOT be used for
meningitis, etc)

Tetracyclines cause problems with teeth because they bind ______ and cause
discoloration - Answer calcium

What type of tetracycline product would cause Fanconi-like syndrome? - Answer
expired (out of date)

Two things that happen to expired tetracyclines that lead to renal toxicity - Answer
dehydration & epimerization

tetracycline side effect due to accumulation in the skin - Answer phototoxicity (abnormal

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