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PMD 605 Drug Actions I - Micrometrics Study Set Exam
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PMD 605 Drug Actions I -Micrometrics Study Set Exam
Define micrometrics. - Answer the science and technology of small particles and
includes the study of fundamental and derived properties of individual as well as a
collection of particles
Dissolution - Answer the surface area per unit (aka specific surface) is increased by
reduction in particle size. the increase in surface area by particle size reduction
increases the rate of drug dissolution (i.e. smaller size, bigger surface area)
appearance - Answer feel, texture, and color of certain drug excipients depend on
particle size
flowability - Answer flow properties of powders depend on particle size, size distribution
and particle shape
compressibility - Answer physical properties of powders such as compressibility,
porosity, and bulk density depend on particle size and size distribution
weight uniformity - Answer weight uniformity of oral solid dosage forms depends on
particle properties
mixing - Answer provides a greater dose uniformity; more uniform if the ingredients are
of approximately the same size
drying - Answer of wet masses may be facilitated by size reduction, which increases
surface area and reduces the distance that a moisture must travel within the particle to
reach the outer surface
List the FIVE fundamental powder properties. - Answer 1. particle size and size
distribution
2. particle volume
3. particle number
4. particle shape
5. particle surface area
what is a polydisperse powder? - Answer it contains particles of more than one size
The size of a spherical particle can be expressed in terms of its _____________. - Answer
diameter
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