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PMD 605 Drug Actions I Intro To Pharmacokinetics Study Set Exam
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PMD 605 Drug Actions I Intro ToPharmacokinetics Study Set
Exam
Define clinical pharmacokinetics. - Answer the application of pharmacokinetic
principles/methods to drug therapy
- main objectives of clinical pharmacokinetics include optimizing efficacy and
decreasing toxicity of drug therapy
in pharmacodynamics, the effect of a drug present at the site of action is determined by
the drug's ________________________. - Answer binding to a receptor
what are some factors that can affect pharmacokinetics? - Answer - patient compliance
- patient (patho)physiology
- drug interactions
- dosing errors
what are some factors affecting pharmacodynamics? - Answer - drug receptor status
- genetic factors
- drug interactions
- tolerance
pharmacokinetics deals with effects between _____________and______________.
pharmacodynamics deals with relationship between
__________________and_________________. when both PK/PD are combined, they focus on
relationship between ___________________and____________________. - Answer
concentration, time; effect, concentration (log); effect, time
the plasma drug concentration-time curve is generated from _____________________. -
Answer blood samples taken at various time intervals
depending on administration route, some drugs will require ___________________ before
reaching systemic circulation. - Answer absorption
over time, drug is eliminated from the body primarily via ____________________ (mainly in
liver) and/or kidney __________________. - Answer metabolism, excretion
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