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PMCOL 344 Drug List Study Set Exam
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PMCOL 344 Drug ListStudy Set Exam
Omeprazole - Answer Inhibits acid secretion in the stomach via the proton pump
Cimetidine - Answer Inhibits histamine and gastrin stimulated acid secretion via the H2
receptor.
Antacids - Answer Inorganic weak base salts that neutralize acid in the stomach.
Alginates - Answer Negative polysaccarides from algae that absorb water and coat
stomach
Bisthmuth chelate - Answer Kills pathogens and bacteria and prevents adherences to
wall.
Sucralflate - Answer Complex of Al(OH)3 dissociates and OH forms gel by attaching to
glycoproteins
Misoprostol - Answer Stable PGEI2 analogue that increases mucus (EP4), increase
bicarbonate (EP1&2), Inhibit histamine production (EP2&3)
Hyoscine - Answer Blocks the muscarinic receptor antagonist acting at the vomiting
centre and vestibular nuclei
Metoclopramide - Answer Inhibits vomiting signaling and promotes GI motility, crosses
the BBB causing dyskinesia
Domperidone - Answer Inhibits vomiting signaling and promotes GI motility, doesn't
cross the BBB
Ondansetron - Answer Blocks the 5HT3 receptor stopping the vomiting signal by acting
on the CTZ and visceral afferents
Nabilone - Answer Anti-emetic cannabinoid
Dexamethasone - Answer Glucocorticoid that inhibits all stages of inflammation
Aprepritant - Answer NK1 receptor antagonist
Oral Rehydration - Answer Restore fluid and electrolyte balances. Addition of glucose
aids in Na/water absorption
Spasmolytics - Answer Cause relaxation of the gut to increase time for reabsorption and
, transit time
Atropine - Answer Blocks Ach from contracting the muscle leading to relaxtion. Very
predictable symptoms
Morpine/Codine/Diphenoxalate - Answer Opiates stop the release of Ach from nerve
leading to less contraction
Loperamide - Answer Synthetic opioid agonist. Effects GI muscle and ENS to reduce
contraction
Methylcellulose - Answer Polysaccharide polymer not broken down by gut. Binds water
in the gut reducing fluid volume. Forms hydrated bulky mass. Promotes peristaltic reflux
Lactulose - Answer Disaccharide of fructose and glucose. Osmotically active molecules
that draws water into lumen.
Senna - Answer Increase electrolytes and water secretion. Increases peristalsis.
Directly stimulates nerves in the myenteric plexus
Cholinomimetics/Cholinesterase inhibitors - Answer Enhance GI contractions but they
are uncoordinated so they produce little peristaltic activity
Cisapride - Answer 5HT4 agonist. Targets presynaptic neurons that stimulate the
myenteric plexus. Causes Long QT syndrome due to blockage of HERG channels.
Tegaserod - Answer 5HT4 agonist. Targets presynaptic neurons that stimulate the
myenteric plexus
Pruclopride - Answer Newest 5HT4 agonist. Targets presynaptic neurons that stimulate
the myenteric plexus
Lubiprostone - Answer PGE1 analog. Increases cAMP via EP4 receptors to promote Cl
channels (CFTR) and promote fluid secretion
Sulfazalazine - Answer Prodrug that is converted to 5-ASA. Scavenges free radicals and
inhibitis prostaglandin
Infliximab - Answer Chimeric antibody that stop TNF-alpha from causing inflammation
Adalimumab - Answer Humanized antibodies that stop TNF-alpha from causing
inflammation. Also suppresses formation of IL6/1. Causes cellular depletion via CD or
ADCC
Galimumab - Answer Humanized antibodies that stop TNF-alpha from causing
inflammation
Vedolizumab - Answer Anti-alpha 4 beta 7 intern. Prevents T cell activation
Ustenkinumab - Answer Blocks the binding of IL-12 and IL-23 to cells for the response.
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