Pharmacotherapeutics for Advanced Practice Nurse Prescribers
1. Nurse practitioner prescriptive authority is regulated by who?: The State
Board of Nursing for Each State
2. What is the benefits of having an APRN prescriber?: APRN's care for patients
more holistically and include patients in making decisions regarding their care
3. What does clinical judgement in prescribing include?: Factoring in the cost
of the particular
4. What is included in the criteria for choosing and effective drug for a
disorder?: Consulting nationally recognized guidelines for disease management
5. NP's thrive under the new health-care reform because of what?: NP's have
the ability to control care cost and improve patient outcome
6. Nutritional intake and lab results reflect hypoalbuminemia; why is this
important for prescribers?: The Distribution of drugs to target tissues may be
affected
7. Drugs that have an significant first-pass effect what?: they are rapidly
metabolized by the liver and may have little if any desired action
8. The route of excretion of a volatile drug will likely be?: Lungs
9. Medroxyprogesterone (Depo Provera) is prescribed IM to create storage
reservoir of the drug. What are storage reserviors>: Increased the length of
time a drug is available and active
10. Why is Cephalexin given every 8 hours? What knowledge of the drug
does the NP know?: Half Life
11. Azithromycin doing requires that the first day's doing be twice those of
the other four day; This is considered a loading does. What is a loading
dose?: Rapidly actives drug levels in the therapeutic range
12. The point in time on the drug concentration curve that indicates the first
sign of a therapeutic effect is the:: Onset of action
13. Phenytoin required that a trough level be drawn. When and why are peak
and trough levels are done: To determine if a d rug is in the therapeutic range
14. Drugs that are receptor agonists may demonstrate what property?:
Concentrations will produce an adverse effect
15. Factors that affect gastric drug absorption include: Lipid solubility of the
drug
16. Drugs that are receptors antagonists, such as beta-blockers, may cause
what?: An exaggerated response if abrupt discontinues
17. Drug administration via IV:
1) need to be lipid soluble in order to absorb easily
, .
2) Begin distribution in the body immediately
3) Are easily absorbed if they are monitized
4) May use pinocytosis to be absorbed: Are easily absorbed if they are monitized
18 What is the combination effect when a medication is added to a regimen
for a synergistic effect?: Greater than the sum of the effects of each drug
individually
19. Which of the following statements about bioavailability is true?
1) Bioavailability issues are especially important for drugs with narrow
therapeutic ranges or sustained-release mechanisms.
2) brands of a drug have the same bioavailability.
3) Drugs that are administered more than once a day have greater
bioavailability than drugs given once daily.
4) Combining an active drug with an inert substance does not affect
bioavailability.: Bioavailability issues are especially important for drugs with
narrow therapeutic
20. Which of the following statements about the major distribution barriers
(blood-brain or fetal-placental) is true?
1) Water soluble and ionized drugs cross these barriers rapidly.
2) The blood-brain barrier slows the entry of many drugs into and from brain
cells.
3) The fetal-placental barrier protects the fetus from drugs taken by the
mother.4) Lipid-soluble drugs do not pass these barriers and are safe for
pregnant women: The blood-brain barrier slows the entry of many drugs into
and from brain cells.
21. What is the purpose of phase I and phase II of metabolism in the liver?: -
Change drug molecules to a form that an excretory organ can excrete
22. What happens to the metabolites after they are metabolized in the liver?:
the metabolite may or may not be more active than the parent drug and they are
totally deactivated so they are excreted without and effect; it depends on the
medication being given
23. What causes the body to increased the excretion of a drug through the
renal system: Unbinding a nonvolatile drug from plasma proteins.
24. What is "steady state"?: When the amount of the drug in the body remains
constant
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