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GMS6504 Exam Questions And Accurate Answers
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GMS6504 Exam Questions And Accurate Answerswhich of the following would best be described as a system independent parameter
determining pharmacological response?
•the number of receptors present
•the cellular cascade
•pharmacokinetics
•receptor affinity for the ligand
•presence of an antagonist - Answer receptor affinity for the ligand
when taking a natural agonist and converting it to an antagonist using synthetic
chemistry, what are the desired effects on affinity and efficacy?
•both increase
•both decrease
•affinity increases, efficacy decreases
•affinity decreases, efficacy increases - Answer affinity increases, efficacy decreases
in the langmuir equation, which variable represents the proportion of receptors that are
bound by ligand?
•r
•D
•Kd
•Rt
•DR - Answer r
,if a ligand has an intrinsic activity, alpha, of 0.54, this ligand is best considered a.
•full agonist
•partial agonist
•antagonist
•inverse agonist - Answer partial agonist
If you do a cell culture experiment where you exogenously express a receptor in cells,
which variable in the equation R=f[α•r•Rt] are you most directly controlling?
•R
•f
•α
•r
•Rt - Answer Rt
with an efficacy driven agonist, reducing the number of receptors present will shift the
response curve.
•up
•down
•left
•right
•not at all - Answer right
applying the two state theory of receptors to an ion channel, which state[s] would be
active? select all that apply.
, •Rclosed
•Ropen
•ARclosed
•ARopen
•none would be active - Answer •Ropen
•ARopen
in a two state system that allows for spontaneously active receptors, increasing the
expression levels of receptor in the absence of agonist will have what effect on measured
response?
•increase
•decrease
•no effect - Answer increase
in the extended ternary complex model of receptors, which state[s] will result in
subsequent downstream signaling? select all that apply.
•Ri
•Ra
•ARi
•ARa
•ARaG
•RaG - Answer •ARaG
•RaG
If a system contains no constitutive activity of a receptor, what will be the effect of adding
an inverse agonist to the system on the measured response in the absence of any other
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