Exam (elaborations)
GMS6504 Exam 2 Questions And Accurate Answers
- Course
- Institution
GMS6504 Exam 2 Questions And Accurate Answers...
[Show more]
Content preview
GMS6504 Exam 2 Questions And Accurate AnswersWhat 4 factors determine wether a drug is good or bad? - Ans 1. Lipinski's Rule of 5
2. Chemical Reactivity: Good or bad
3. Functional Groups
4. Drug Targets
Name atleast 3 Lipinski's Rules (Basic) - Ans 1. Molecular mass greater than 500 Da
2. High Lipophilicity, LogP greater than 5
3. More than 5H bond donors (FH,NH,OH)
4. More than 10H bond acceptors (O,F,N)
When we have high values of Lipinski's Rules of 5, what does this tell us? -Answer We
can find out if we have poor absorption and permeation or not
Name atleast 3 Lipinski's Rules (Improved) - Answer 1. Molecular Mass from 160-500 Da
2. Molar Refractivity from 40 to 130
3. Number of atoms from 20 to 70 H bond donors and acceptors.
What is Partition Coefficient? - Answer Its the ratio of equilibrium concentration of a
dissolved substance in a 2 phase system. Typically, it contains ocantol and water.
Why do we use LogP for partition coefficient? - Answer We measure with Log10 so that
we have a more managable range for lipophilicity.
How can we determine if the chemical reactivity is good or bad? - Answer 1. Is there
nonselective or selective modification of proteins/nucleic acids?
2. Is it labile in biological systems?
, What most common functional groups are found labile in biological systems? - Answer 1.
Esters
2. Disulfide Bonds
Adavantages of function groups being labile in biological systems and how it affects
chemical reactivity? - Answer Can be incorporated in the design of a pro-drug approach
because they are known to break down.
DISadavantages of function groups being labile in biological systems and how it affects
chemical reactivity? - Answer Prone to breakdown in vivo.
Name 2 most common chemically reactive functional groups - Answer 1. Epoxides
2. Micheal Acceptor
Give one example of when we would use a pro-drug approach. When normal physiology
will not allow the drug to pass through the BBB or membrane. Thus, we use a pro-drug to
alter the properties of the molecule to allow passage.
What functional group is the most commonly used for pro-drugs? Esters
What makes for an easily "druaggable" target? 1. Enzymes: Kinases, Phosphates
2. Cell surface receptors: GPCR's, RTK
What is a hard "undruaggable" target? - Answer 1. Transcription factors
2. Protein-Protein interaction
2 ways to address undruggable targets? - Answer 1. Synthetic Lethality
2. Genome Editing
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Easton. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $12.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
72841 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now