,8. administration has variable and erratic absorption. n: Rectal
administration
9.4. Steady state (SS): absorption. n is usually reached within 4-5 half
lives of drug.
10.Half-life of a drug is: how long it takes for half the drug to be excreted
from the body. Determines how frequently the drug must be
administered. Predicts how long toxic effects can last.is constant with
first-order pharmacokinetics of a drug.
11.Zero-order (nonlinear) pharmacokinetics: means a drug is metabolized
at a constant rate per unit time.
12.CYP3A4 substrate drugs: may have enhanced activity if any CYP3A4
inducer drugs are used along with it.
13. Drug development process involves these steps according to the FDA:-
: Discovery: laboratory research to develop the new drug. Preclinical
research with animal testing for safety (Phase I). Clinical research on
,human subjects for medication safety (Phase II). Clinical research in
humans comparing the new drug
to accepted medications placebo depending on the study (Phase III).
FDA review of the results to determine approval. Post marketing study
to identify adverse effects not found in earlier clinical studies (Phase IV)
14.2. Medication safety organizations: The Institute for Safe Medication
Practices (ISMP) The Institute of Medicine (IOM) The Joint Commission
The National Coor- dinating Council for Medication Error Reporting and
Prevention (NCC MERP) Food and Drug Administration (FDA) Safe Use
Initiative
15.Two basic type of ADRS:: pharmacological and idiosyncratic.
16.85% to 90% of ADRS: are pharmacological.
17.Adverse drug reactions are usually preventable,: frequently occur in a
hos- pital or nursing home setting, and include medication errors,
adverse drug effects, and allergic idiosyncratic type reactions.
, 18.ADRS are not commonly reported;: the FDA does not mandate that
ADRS be reported.
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller LECGRADER. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $12.49. You're not tied to anything after your purchase.
