1 | P a g e | © copyright 2024/2025 | Grade A+
CMB2004 Questions and Answer |
Latest Update 2024/2025
What is the specific/adaptive immunity?
~~> induced by exposure to an infection, very specific and has memory
Describe the receptors in the specific immune response
~~> clonaly distributed, a large repitoire at a low frequency
What is clonal selection?
~~> during development, cells recognising self material are destroyed
leaving only those recognising non-self
Whats the role of clonal selection?
~~> reduces the repertoire leaving a pool of mature naive lymphocytes
which can proliferate and differentiate on activation to form effector cells
What are TCRs?
~~> T cell receptors, expressed by T cells and are always membrane bound
Master01 | September, 2024/2025 | Latest update
, 2 | P a g e | © copyright 2024/2025 | Grade A+
What do TCRs recognise?
~~> processed peptides on MHC on APC
What is this?
~~> TCR complex
What are the four domains of a TCR?
~~> heterodimer of alpha and beta
What can the four domains of a TCR sometimes be?
~~> gamma and delta
Whats CDR?
~~> complementary determining region
How many CDRs does a TCR have?
~~> each chain has 3 so 6 in total
Whats an MHC?
Master01 | September, 2024/2025 | Latest update
, 3 | P a g e | © copyright 2024/2025 | Grade A+
~~> essential for the acquired immune system to recognize foreign
molecules
What does MHC stand for?
~~> major histocompatibility complex
Whats different between MHCI and MHCII
~~> different structures and expression patterns presenting peptides from
different sources
How was MHC first discovered?
~~> in transplant rejection
Which cells are MHCI present on?
~~> all nucleated cells
What are the types of MHCI?
~~> HLA-A/B/C
What domains is the MHCI made of?
Master01 | September, 2024/2025 | Latest update
, 4 | P a g e | © copyright 2024/2025 | Grade A+
~~> alpha 1 2 3 and beta2 microglobulin
In MHCI, which domains are Ig-like?
~~> alpha 3 and beta2 micro globulin
In MHCI, which domains are polymorphic/peptide binding?
~~> alpha 1 and 2
What does MHCI bind with?
~~> CD8+ cells
Which cells are MHCII present on?
~~> APC/cytokine active cells
What are the types of MHCII?
~~> HLA-DQ/DR/DP
What domains is the MHCII made of?
~~> alpha 1/2 and beta 1/2
Master01 | September, 2024/2025 | Latest update
CMB2004 Questions and Answer |
Latest Update 2024/2025
What is the specific/adaptive immunity?
~~> induced by exposure to an infection, very specific and has memory
Describe the receptors in the specific immune response
~~> clonaly distributed, a large repitoire at a low frequency
What is clonal selection?
~~> during development, cells recognising self material are destroyed
leaving only those recognising non-self
Whats the role of clonal selection?
~~> reduces the repertoire leaving a pool of mature naive lymphocytes
which can proliferate and differentiate on activation to form effector cells
What are TCRs?
~~> T cell receptors, expressed by T cells and are always membrane bound
Master01 | September, 2024/2025 | Latest update
, 2 | P a g e | © copyright 2024/2025 | Grade A+
What do TCRs recognise?
~~> processed peptides on MHC on APC
What is this?
~~> TCR complex
What are the four domains of a TCR?
~~> heterodimer of alpha and beta
What can the four domains of a TCR sometimes be?
~~> gamma and delta
Whats CDR?
~~> complementary determining region
How many CDRs does a TCR have?
~~> each chain has 3 so 6 in total
Whats an MHC?
Master01 | September, 2024/2025 | Latest update
, 3 | P a g e | © copyright 2024/2025 | Grade A+
~~> essential for the acquired immune system to recognize foreign
molecules
What does MHC stand for?
~~> major histocompatibility complex
Whats different between MHCI and MHCII
~~> different structures and expression patterns presenting peptides from
different sources
How was MHC first discovered?
~~> in transplant rejection
Which cells are MHCI present on?
~~> all nucleated cells
What are the types of MHCI?
~~> HLA-A/B/C
What domains is the MHCI made of?
Master01 | September, 2024/2025 | Latest update
, 4 | P a g e | © copyright 2024/2025 | Grade A+
~~> alpha 1 2 3 and beta2 microglobulin
In MHCI, which domains are Ig-like?
~~> alpha 3 and beta2 micro globulin
In MHCI, which domains are polymorphic/peptide binding?
~~> alpha 1 and 2
What does MHCI bind with?
~~> CD8+ cells
Which cells are MHCII present on?
~~> APC/cytokine active cells
What are the types of MHCII?
~~> HLA-DQ/DR/DP
What domains is the MHCII made of?
~~> alpha 1/2 and beta 1/2
Master01 | September, 2024/2025 | Latest update
