CMB2001 Questions and Answer | Latest Update 2024/2025
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Course
CMB2001
Institution
CMB2001
Why does RNA degradation take place?
~~> Damaged mRNA
Incorrectly transcribed/processed mRNA
Control gene expression
What 2 things control mRNA levels?
~~> Transcription and turnover
Why is turnover important?
~~> If mRNA has a ridiculously long half life and doesn't go away,...
Helps translation because it helps reinitiation of translation
Stabilises the RNA because most processes that target RNA for degradation
start through either the cap or the poly(A) tail and to get to these you have
to break open the circular structure
Describe Phase 1 of mRNA degradation
✓ ~~> The breakdown of the RNA
Start by either removing the Poly(A) tail and/or the cap to make it accessible
for exonucleases
Decapping enzymes - DCP1, DCP2
Endonucleases - Argonaute, Swt1, Smg6
Deadenylases (remove the poly(A) tail) - Ccr/Not complex
Master01 | September, 2024/2025 | Latest update
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