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MCMP 422 Past Exam Questions And Accurate Answers
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MCMP 422 Past Exam Questions And AccurateAnswers
Which of the following statements about the lymph system is TRUE? - Answer The lymph
system is connected to the vascular system
Which of the following is true about the transporter associated with antigen processing
(TAP)? - Answer TAP is an ATP-dependent, membrane-bound transporter
Which of the following statements is correct concerning membrane-coding (MC) exons
of immunoglobulin genes? - Answer MC exons encode for transmembrane hydrophobic
amino acids that associate with the B-cell membrane
Spherical regions in lymph nodes containing areas that are packed densely with
proliferating B cells are termed - Answer germinal centers
What are the TWO major consequences of cytokines released by activated
macrophages? - Answer -Some cytokines may function as chemoattractants
Some cytokines can act on the endothelial cells at a blood vessels to increase vascular
permeability and cause vasodilation
act as cellular messengers by transporting degraded pathogens to lymphoid organs -
Answer Dendritic cells
Why does an infected tissue site swell during inflammation? - Answer Tissues swell due
to increased permeability of capillaries resulting in fluid accumulation
NK cells are one of the components of innate immunity. Which of the following is/are
TRUE regarding NK cells? - Answer NK cells bind to both infected and healthy host cells
,How do the RAG proteins know how to pair gene segments during somatic
recombination? - Answer Each gene segment has a specific DNA sequence
(recombination signal sequence) that needs to pair with another type of recombination
signal sequence for recombination to occur
All of the following acute-phase proteins increase in concentration in the plasma during
inflammation with the exception of - Answer albumin
Many things happen after a neutrophil phagocytoses a pathogen. Which of the following
statements is FALSE? - Answer Neutrophils will live a long time after phagocytosis so
they can form a living net to capture pathogens
In relation to the discussion topic in Week 1 on fecal transplants - which of the following
statements is FALSE? - Answer Probiotics work just as well as a replacement for fecal
transplants
Which of the following does not describe defensins? - Answer highly conserved with few
variants
Which of the following is the correct order of events when TLR4 binds to a pathogen
antigen? - Answer TLR4 binds to lipopolysaccharide; kinase cascade occurs; NFKB
translocates to the nucleus; transcription of inflammatory cytokines
A hiker was bitten by a rattlesnake. The hiker was administered the antivenin, ACP
(antivenin crotalidae polyvalent), and recovered from the snake bite but he did develop
serum sickness. The serum sickness is due to an immune response to the - Answer
Horse polyclonal antibodies in the ACP
The region of a protein that an antibody recognizes - Answer Epitope
The immunological consequence of SCID disease due to a genetic defect in either
RAG-1 or RAG-2 genes is - Answer lack of somatic recombination in T-cell receptor and
, immunoglobulin gene loci.
Peptides that bind to a particular MHC isoform usually have either the same or
chemically similar amino acids at two to three key positions that hold the peptide tightly
in the peptidebinding groove of the MHC molecule. These amino acids are called _____
and the combination of these key residues is known as its _____. anchor residues;
peptide-binding motif
When effector lymphocytes secrete _____, an inflammatory response ensues. - Answer
cytokines
Which of the following is NOT a component of the assembled inflammasome complex? -
Answer IL-1β
Of the following, which most correctly describes the route an MHC class II molecule
would take to present peptides? - Answer MHC class II binds Li in the ER --> Li is
degraded and leaves only the Clip peptide binding to MHC class II --> Clip dissociates
and antigen peptide binds to MHC II
Plasmacytoid dendritic cells Answer - When activated, produce large amounts of the
type 1 interferons - Have a cytoplasmic morphology which resembles that of antibody
producing plasma cells
Soluble effector molecules are effective when encountering pathogens in/on Answer -
extracellular spaces - epithelial surfaces - interstitial spaces - lymph
Which of the following is NOT characteristic of innate immunity? Answer improvement in
recognition of the pathogen during the response
Which of the following statements is TRUE about antibody binding and structure? -
Answer Antibodies contain several immunoglobulin domains in each chain
All of the following complement proteins form a pore in the membrane of the pathogen
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