NR 565 Midterm exam point – Download To Score An A+
Exam Week 1:
• Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to: Increased dosages needed of
drugs metabolized by 2D6, such as the selective serotonin reuptake inhibitors
• The National Standards of Culturally & Linguis...
NR 565 Midterm exam point – Download To Score An A+
Exam
Week 1:
• Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to: Increased dosages needed of
drugs metabolized by 2D6, such as the selective serotonin reuptake inhibitors
• The National Standards of Culturally & Linguistically Appropriate Services are required to be
implemented in all: Organizations that receive federal funds
• Warfarin (coumadin) resistance may be seen in patients with VCORC1 mutation, leading to:
Decreased response to warfarin
Week 2:
• what is phase 3 trials: who do they run it on (Human safety & efficacy studies). Phase III trials
are controlled and uncontrolled clinical trials of a drug’s safety and efficacy in hospital and
outpatient settings. Phase III studies gather precise information on the drug’s efficacy for
specific indications, determine whether the drug produces a broader range of adverse effects
than those exhibited in the small study populations of phases I and II studies, and identify the
best way of administering and using the drug for the purpose intended
• off label drugs who are they approved by FDA. Off-label prescribing is: Legal if there is
scientific evidence for the use. Offlabel use includes use of an FDA-approved drug in a dose or
route for which it was not approved or for a clinical indication other than the FDA-approved use.
• The U.S. Food & Drug Administration regulates: The official labeling for all prescription &
over-the-counter drugs
• The ailment that generates the greatest over-the-counter annual drug sales is: Cough & colds
Week 3:
• There is a narrow margin between first appearance of adverse reaction to AChE inhibitors &
serious toxic effects. Adverse reactions that require immediate action include: Fasciculations of
voluntary muscles
• Beta blockers are prescribed for diabetics with caution because of their ability to produce
hypoglycemia & block the common symptoms of it. Which of the following symptoms of
hypoglycemia is not blocked by these drugs & so can be used to warn diabetics of possible
decreased blood glucose? Diaphoresis
• 60 year old male with TN beta-adrenergic antagonist, effect of the beta blocker do:
reduce cardiac contractility, reduce HR and BP?? A 60-year old male is being treated for
hypertension with a beta-adrenergic antagonist (beta-blocker). Which of the following is
an expected cardiovascular effect of the beta-blocker class of drugs? Reduced cardiac
contractility
This study source was downloaded by 100000883055406 from CourseHero.com on 09-16-2024 14:11:43 GMT -05:00
, • HTN and BPH. Doxazosin. What are the drugs of choice for treating
hypertension in older men with concomitant BPH? Alpha1-adrenergic
antagonists (except alfuzosin, tamsulosin, and silodosin, which are not
approved to treat HTN) are the drugs of choice for treating HTN in older men with
concomitant BPH. What are they? Doxazosin
orthostatic hypotension is one of the main concerns when initiating alpha-1
blocker
• Define bioavailability? The percentage of the administered dosage that enter the blood
stream. Pharmacokinetic factors that affect prescribing include: bioavailability
Dose response curve answer choice
• A patient with anxiety & depression may respond to: Buspirone (Buspar) & an SSRI combined
o An appropriate first-line drug to try for mild to moderate generalized anxiety disorder
would be: Buspirone (Buspar)
• Dosage of Cymbalta and how do you adjust it: 40–60 mg/day, max 60 mg
• What route is effected with firs-pass Metabolized first pass in the liver: PO, IV, IM. Drugs
that have a significant first-pass effect: Are rapidly metabolized by the liver & may have little if
any desired action.
• When two or more medications are prescribed that are highly protein bound, what is the
clinical outcome? Coumadin and protein binding. What happens when you give two
drugs together increases level Warfarin is 98% bound to plasma proteins so even
if the binding of a second drug to plasma proteins displaces even a small fraction
of warfarin, it can have a dramatic increase in the effects of warfarin
• Coumadin and NSAID interact. When prescribing NSAIDS, a complete drug history should be
conducted as NSAIDs interact with these drugs: Warfarin (coumadin), an anticoagulant
• Allergic Reaction that involved angioedema and what do you give. Epi? Patients should be
monitored for indications of angioedema. Suspect angioedema in any patient who calls the next
morning after taking the first dose and complains of voice changes or swollen lips or tongue.
Stop the drug immediately. The symptoms recede as the drug is eliminated. Protection of the
airway is rarely needed, but careful assessment of airway status is required.
o A potentially life-threatening adverse response to angiotensin-converting enzyme
inhibitors is angioedema. Which of the following statements is true about this adverse
response? 1. Swelling of the tongue or hoarseness are the most common symptoms.
This study source was downloaded by 100000883055406 from CourseHero.com on 09-16-2024 14:11:43 GMT -05:00
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