Pmcol 200 Drugs Exam Study Guide
Penicillin and cephalosporin - answerclass: cell wall inhibitor
transpeptidase inhibitor
bacteriocidal
beta lactam ring
beta-lactamases - answerbacterial enzymes that hydrolyze the beta-lactam ring of penicillins
and cephalosporins
made by staphylococci and o...
Penicillin and cephalosporin - answer✔class: cell wall inhibitor
transpeptidase inhibitor
bacteriocidal
beta lactam ring
beta-lactamases - answer✔bacterial enzymes that hydrolyze the beta-lactam ring of penicillins
and cephalosporins
made by staphylococci and other gram negative bacteria
beta lactam inhibitors - answer✔calvanulic acid
inhibitor of beta-lactamases
vancomycin - answer✔cell wall inhibitor
inhibits peptidoglycan cross linking
NOT a beta-lactam
Sulfonamides - answer✔folic acid inhibitor
competes with PABA
Acyclovir - answer✔antiviral
nucleoside analog - DNA chain termination
Amantadine - answer✔antiviral
inhibits viral uncoating of influenza A - blocks proton transfer through M2, blocking
acidification and initiation of viral transcription
Zanamivir - answer✔Antiviral. Inhibits NA in Influenza => viral aggregation; unable to exit
host cell; and reduced spread in airways.
cyclophosphamide - answer✔alkylating agent
most susceptible in late G1/S
covalently links chemical groups in NA, cross-links DNA and breaks strands
cisplatin - answer✔alkylating agent
platinum analog
leads to inter-strand crosslinks, leading to inhibition of DNA synthesis and function
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