PMCOL 200 – FINAL Exam Questions With Correct Answers
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Course
Pmcol 200
Institution
Pmcol 200
PMCOL 200 – FINAL Exam Questions With
Correct Answers
When are immunosuppressant drugs used - answer1. Suppression of rejection of transplanted
organs and tissues
2. Suppression of 'Graft-Versus-Host' disease
3. Auto-immune diseases
Tamoxifen - answerselective estrogen receptor antagonist
...
PMCOL 200 – FINAL Exam Questions With
Correct Answers
When are immunosuppressant drugs used - answer✔1. Suppression of rejection of transplanted
organs and tissues
2. Suppression of 'Graft-Versus-Host' disease
3. Auto-immune diseases
Cetuximab - answer✔EGFR inhibitor and monoclonal antibody (against extracellular domain)
Anthracyclines (doxorubicin) - answer✔antibiotic
inhibit DNA topoisomerase
generates free radicals
has high affinity binding to DNA
binds the cell membrane to alter fluidity and ion transport
Captothecins - answer✔stabilise DNA topoisomerase (topi reduce torsional strain thru breakage
and resealing)
increases the single stranded breaks in DNA
Taxanes - answer✔paclitaxel
promotes microtubule assembly, inhibiting mitosis
derived from the pacific yew tree
rate limiting factor for purine synthesis - answer✔Production of inosine monophate (IMP)
(also alters function/synthesis of RNA/DNA)
Alkylating agents - answer✔covalently link to chemical groups
Lead to cross-linking between strands of DNA and strand breakage
cisplatin - answer✔platinum analogue
alkylating agent
leads to inter-strand crosslinks leading to inhibition of DNA synthesis and function
Adverse effects of anti-cancer drugs occur where and why - answer✔in rapidly growing tissues,
such as bone marrow, intestinal mucosa, and reproductive system
drugs are carcinogenic and it is dose related
(adverse) symptoms of anti cancer drugs - answer✔impaired immune system, diarrhea, hair
loss, nausea and vomiting
Primary resistance - answer✔develops spontaneously in the absence of prior exposure to anti-
cancer drugs
e.g. p53 mutations
Acquired Resistance - answer✔develops in response to a given anticancer agent
three shapes of bacteria - answer✔rod/bacillus
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