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Exam (elaborations)

PMCOL 343 Drugs Exam Questions With Correct Answers

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  • PMCOL 343
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  • PMCOL 343

PMCOL 343 Drugs Exam Questions With Correct Answers Thioamides - answerinhibit TPO block orgnaification and coupling inhibition of peripheral T4-> T3 conversion adverse - cause agranulocytosis slow clinical response radioactive iodine - answer127 - emits gamma rays - used for imaging 131...

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  • September 17, 2024
  • 8
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • PMCOL 343
  • PMCOL 343
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PMCOL 343 Drugs Exam Questions With
Correct Answers

Thioamides - answer✔inhibit TPO
block orgnaification and coupling
inhibition of peripheral T4-> T3 conversion


adverse - cause agranulocytosis


slow clinical response

radioactive iodine - answer✔127 - emits gamma rays - used for imaging


131 - gamma + beta
has cytotoxic action - destruction of follicle cells
onset 1-2 months
localized action
may develop hypothyroidism

iodide/iodine - answer✔inhibits organifcation/proteolysis


thyrotoxic cells and before surgery
reduces gland size and vascularity
rapid improvement


disadvantage
- delay in response to thioamide or radioactive I

, ©THEBRIGHTSTARS 2024
- temporary inhibition
- can cause thyrotoxicosis upon WD

anion inhibitor - answer✔CLO4-
competitive inhibitor of NIS
reduce iodide uptake
can be overwhelmed by high iodide concentration

Beta-adrenergic antagonists - answer✔Propanolol


antagonize the sympathetic effects of thyrotoxicosis
reduce tachycardia, arrhythmia, tremor and anxiety
use
- prep for surgery
- initial treatment of hypothyroidism

Guanethidine - answer✔noradrenergic blocker
used to relieve exophthalmos
relaxation of symp innervated SM that causes eyelid retraction

Tamoxifen - answer✔partial agonist inhibitor of estrogen receptors


estrogenic effects:
- bone
- plasma lipids
- endometrium
- blood coagulation


Anti estrogenic:
- breast tissue
- treatment of breast cancer or to prevent cancer in high risk women

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