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BCHM 307 Exam 2024 with Questions Solved 100% Correct |Verified Solutions
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BCHM 307 Exam 2024 with QuestionsSolved 100% Correct |Verified
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Which type of DNA repair is used to remove and replace a single modified base that
cannot be converted back to a normal base by a direct repair process?
a. Mismatch repair
b. Base excision repair
c. Nucleotide excision repair
d. DNA photolyase - Answer b. Base excision repair
Which of the following is found in high concentrations in telomeres?
a. G
b. C
c. T
d. A
e. Pyrimidines - Answer a. G
Which of the following best describes the nucleic acid complex formed during
DNA polymerization?
a. One DNA-RNA hybrid and one single stranded DNA
b. One DNA-RNA hybrid with other DNA strand bound to an RNA molecules on
RNA polymerase
,c. There is no interaction between growing RNA and DNA
d. Two DNA-RNA hybrids since both DNA strands are transcribed simultaneously
e. None of the above - Answer a. One DNA-RNA hybrid and one single stranded DNA
Addition of a(n) ___ group to certain lysine residues of a histone protein makes the
region of chromatin transcriptionally ___; addition of a(n) ___ group to certain
lysine residues makes the region of chromatin transcriptionally ___.
a. Acetyl, silent; methyl, active
b. Methyl, highly active; acetyl, active
c. Methyl, silent; phosphate, active
d. Methyl, silent; acetyl, active
e. Phosphate, silent; methyl, active - Answer d. Methyl, silent; acetyl, active
During termination, Rho acts as a ___.
a. Helicase
b. NTP hydrolase
c. Polymerase
d. Ligase
e. Single-stranded binding protein - Answer a. Helicase
What DNA sequence is found on the template strand at the termination of prokaryotic
transcription?
a. Series of CpG islands
b. Series of CG repeats followed by string of 10-12 U
c. Section of Z-DNA followed by repetitive CAT
sequence d. Series of TATA boxes
,e. Palindromic sequence followed by poly(A) region - Answer e. Palindromic sequence
followed by poly(A) region
An E. Coli has ___ replication fork(s) on its single chromosome; humans have
___ replication fork(s) on each chromosome.
a. 2, 2
b. 2, many
c. 1, 1
d. many, many
e. 1, 2 - Answer b. 2, many
If the smallest human chromosome is 4.6 x 10^7 base pairs in length, which of the
following is the best estimate of the number of Okazaki fragments resulting from
its replication?
a. 300,000
b. 30
c. 30,000
d. 3,000
e. 300 - Answer a. 300,000
Which of the following is correctly pairs with its function?
a. DNA ligase- joins the discontinuous segments on the lagging strand
b. RNase H- removal of RNA primer
c. Primase- production of an RNA primer for DNA polymerase
d. Helicase- creates single strand DNA
e. All of the above - Answer e. All of the above
, Without telomeres, what would happen to the ends of eukaryotic chromosomes during
replication?
a. They would be replicated just like the rest of the chromosome
b. They would be shortened
c. They would be lengthened
d. They would be mutated - Answer b. They would be shortened
In the nucleus, DNA is wrapped around ___ to form ___.
a. Polyribose, euchromatin
b. Histones, nucleosomes
c. Ribosomes, heterochromatin
d. Polyarginine, 30-nm fibers - Answer b. Histones, nucleosomes
An antibiotic that interferes with bacterial topoisomerase activity is ___
which specifically inhibits ___.
a. Camptothecin, type II topoisomerase
b. Novobiocin, ATPase
c. Doxorubicin, type IA topoisomerase
d. Ciprofloxacin, DNA gyrase - Answer d. Ciprofloxacin, DNA gyrase
What does a reverse transcriptase do?
a. Replicated DNA in a 3' to 5' fashion
b. Replicates RNA in a 5' to 3' fashion
c. Replicated RNA in a 3' to 5' fashion
d. Converts a DNA genome into an RNA genome
e. Converts an RNA genome into a DNA genome - Answer e. Converts an RNA genome
into a DNA genome
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