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Genetics and Genomics A Grade Exam Questions Solved 100% Correct
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Genetics and Genomics A Grade ExamQuestions Solved 100% Correct
A patient is 34 years old and concerned about possibly being a carrier for HNPCC because his father died
of colon cancer at 39, his father's sister died of colon cancer at age 41, and his brother (aged 37) now
has colon cancer. The brother's testing is negative for all the known mutations associated with inherited
forms of colon cancer. How should this patient be counseled about his risk for colon cancer? -
✔✔Explain that testing for him would be of no benefit because of the current test limitations but that
his family history does place him a high risk.
Which processes of drug response are most subject to genetic variation? - ✔✔Drug activation
or deactivation and duration of drug actions
How do genetic /genomic issues influence individual variation of the response to a specific drug? -
✔✔Polymorphisms if genes encoding metabolizing enzymes
Which organ has the greatest concentration of cytochrome P (CYP) 450 - ✔✔Liver
How are the actions of naturally occurring estrogen changed when a patient is taking a drug that is an
estrogen agonist? - ✔✔Actions are increased.
Which type of parent compound must undergo first phase metabolism to produce the
intended response after it enters the body? - ✔✔A prodrug
What would be the patient's response to a normal drug dose that because of a genetic variation in an
enzyme that prepares the drug for elimination results in a blood drug level that is below the minimum
effective concentration (MEC)? - ✔✔The intended response fails to be produced.
, A patient has a very high concentration of insulin receptors on cells that require insulin for glucose to
enter. How should insulin dosages be adjusted for this patient to have blood glucose levels within the
normal range? - ✔✔Insulin dosages should be decreased because the drug will exert its actions at
lower concentrations.
Which condition or factor improves the initial bioavailability of a drug agonist that has extensive first-
pass loss as a result of the patient's enhanced liver enzyme activity? - ✔✔Administering the drug
by the intravenous route
A patient with a fractured elbow in the emergency department states that he needs morphine for pain
rather than codeine because the last time he had a painful injury, codeine was not effective in managing
his pain. What is the nurse's best response or action? - ✔✔Communicate this information to the
admitting physician.
A patient is identified as an ultra-rapid metabolizer for drugs that are prepared for elimination by
CYP2D6. What effect will this have on the patient's ability to benefit from any active drug that is
metabolized by this enzyme? - ✔✔Both intended responses and side effects decrease.
What is the most likely outcome for a patient with glucose-6-phosphate dehydrogenase (G6PD)
deficiency when he or she takes aspirin or an antimalarial drug? - ✔✔Hemolytic anemia
An Asian American man and his Caucasian wife are both taking warfarin (Coumadin) daily because of
atrial fibrillation. The husband asks why he is prescribed a much smaller than average dose of the drug
to keep his international normalized ratio (INR) at 2.0 and his wife takes the average dose even though
he is taller and heavier than she is. What is the nurse's best response? - ✔✔Many Asian Americans
do not break down warfarin as fast as Caucasians, so the drug is more effective at lower dosages.
Which action reflects promotion of genomic care as part of comprehensive health care? -
✔✔Ensuring that genomic issues potentially influencing a person's health are incorporated into
routine care
Why are general physicians and surgeons NOT considered to be genetics professionals? - ✔✔The
focus of their professional education is the study of medicine rather than genetics.
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