6530 Drugs, Final Exam GMS 6530 With Actual
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Ionotropic Drugs (3)
Dopamine
Dobutamine
Digoxin
Dopamine
b-AR agonist Shock
Before
Dobutamine
b-AR agonist Shock; end stage
Digoxin
Na-K pump inhibitor
Phosphodiesterase (PDE3) inhibitor (1)
Milrinone
Milrinone
PDE inhibitor Shock; end stage
Neurohormonal Modulators (5)
Angiotensin II Modifiers
A-II Receptor Blockers (ARBs)
Beta-AR Antagonists (BBs)
Aldosterone Antagonists
Vasodilators
Angiotensin II Modifiers (3)
,Captopril
Enalapril (Prodrug)
Lisinopril
A-II Receptor Blockers (ARBs) (2)
Valsartan
Candasartan
Beta-AR Antagonists (2)
Metoprolol
Carvedilol
Metoprolol
"(beta1-AR selective antagonist) "
Carvedilol
(beta-AR nonselective, alpha1-AR antagonist)
Aldosterone Antagonists (1)
Spironolactone
Spironolactone
"Blocks mineralocorticoid receptor• Na & water reabsorption• Decreases K excretion•
Reduces sympathetic tone"
Vasodilators (2)
Nitroglycerin/Hydralazine
Sacubitril
Antianginals (5)
Nitrates
B-AR Antagonists
CCBs (main 3, old and new)
Nitroglycerin
dilator: veins > arterioles (NO)
, Hydralazine
dilator: arterioles > veins (NO)
Sacubitril
"inhibits the breakdown of ANP, BNP, Adrenomedullin, Bradykinin thereby enhancing
the vasodilatory, diuretic, natriuretic effects of these counter-regulatory hormones"
Anti-anginals (3)
Nitrates
Beta Adrenergic Antagonists
Calcium Channel Blockers
Nitroglycerin/Isosorbide mono and dinitrate
Nitrates
Metoprolol
Beta-Adrenergic Antagonists
Calcium Channel Blockers (5)
Verapamil
Diltiazem
Nifedipine
Amlodipine
Ranolazine
Amlodipine
Calcium channel blocker with less reflex tachycardia has a slow onset of action and long
half-life
Ranolazine
New Gen/Ca channel blockers
Sodium Channel Blockers (1A)
Na channel blockers that prolong APD
Quinidine
Procainamide
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