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Samenvatting H8 nucleotide metabolisme $3.20
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  3. Universiteit Gent (UGent)
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  5. Bachelor In De Diergeneeskunde
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  7. Biochemie 1

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Samenvatting H8 nucleotide metabolisme
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  • Course
  • Biochemie 1
  • Institution
  • Universiteit Gent (UGent)

GESLAAGD IN EERSTE ZIT!!! Biochemie I wordt gegeven in 2e bachelor Diergeneeskunde, UGent door prof. Meyer. Deze samenvatting gaat over het H8: nucleotide metabolisme. Deze samenvatting bevat zowel het ana- als het katabolisme. Er moet niets zelf worden ingevuld, er zijn voldoende illustraties aanw...

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Document information

  • December 14, 2019
  • January 26, 2020
  • 3
  • 2019/2020
  • Summary

Subjects

  • meyer
  • biochemie
  • g000719a

Written for

  • Universiteit Gent (UGent)
  • Bachelor in de Diergeneeskunde
  • Biochemie 1
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H8: NUCLEOTIDE METABOLISME
INLEIDING

• Nucleïnezuur -> nucleotiden -> veel stikstof => N vinden in H7: niet essentiële AZ
• N’s voor purines en pyrimidines halen we het meest uit de AZ van subklasse 1 (makkelijkste)
o Totaal 2-5 N
• Subklassen die we gebruiken:
o SK1: veel gebruikt, makkelijk om te maken
o SK2: glycolyse metaboliet
• Coënzyme THF => uniek voor nucleotidesynthese => vitamine afhankelijk
o F van Foliumzuur
o  Proteïnen metabolisme: PLP


ANABOLISME

SYNTHESE PURINES

• Uit precursor I(nosine)MP via 2 parallelle wegen AMP/GMP:
o AMP = inbrengextra N via donor asp
o GMP = (oxidatie) + inbrengextra N via donor gln
• Kost ATP!! (activeren)
• THF



• Principe:
➢ 3N-donerende niet essentiële AZ
o Aspartaat = 1N
o Glutamine = 2N
o Glycine = 1N
➢ 3 C-donerende groepen => Inosine – M – P
o Glycine = 2C = geactiveerd
o Co2 = 1C
o THF = 2C
➢ Resultaat = Precursor I(nosine)MP




• Synthese AMP en GMP
➢ Naar AMP
o Extra N door aspartaat
➢ Naar GMP
o Extra N door glutamine

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