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Samenvatting H7 proteïnen metabolisme $3.20
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  3. Universiteit Gent (UGent)
  4.  
  5. Bachelor In De Diergeneeskunde
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  7. Biochemie 1

Summary

Samenvatting H7 proteïnen metabolisme

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  • Course
  • Biochemie 1
  • Institution
  • Universiteit Gent (UGent)

GESLAAGD IN EERSTE ZIT!!! Biochemie I wordt gegeven in 2e bachelor Diergeneeskunde, UGent door prof. Meyer. Deze samenvatting gaat over het H7: proteïnen metabolisme. Deze samenvatting bevat zowel het ana- als het katabolisme met ook het principe van transaminatie. Er moet niets zelf worden ingevu...

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Document information

  • December 14, 2019
  • January 26, 2020
  • 3
  • 2019/2020
  • Summary

Subjects

  • meyer
  • g000719a
  • biochemie

Written for

  • Universiteit Gent (UGent)
  • Bachelor in de Diergeneeskunde
  • Biochemie 1
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1  review

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By: inesmievis • 3 year ago

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H7: PROTEÏNEN METABOLISME
INLEIDING

• “N”: uit voeding of gemaakt van ammoniak
• Back-up voedingstekort: via alfa-ketoglutaraat
o alfa-ketoglutaraat + NH4+ (altijd beschikbaar)
o => GLUTAMAAT maken


PRINCIPE AZ METABOLISME: TRANSAMINATIE

PRINCIPE TRANSAMINATIE

• Je hebt AZ 1 teveel
o => uitwisseling-NH2
• Je hebt AZ 2 te weining
o => =o van alfa-ketozuur 2 wisselen met NH2 van AZ1
• alfa-AZ 1+ alfa-ketozuur2  alfa-ketozuur 1+ alfa-AZ 2
• In functie van behoefte nieuw AZ aanmaken: welk AZ is afh. C-skelet
waarmee je wisselt
• Reactie kost mij niks => energetisch gunstig

MECHANISME TRANSAMINATIE

• Transaminase werkt via reversiebele“ping-pong” kinetiek:
o Richting reactie afhankelijk van [S] en [P] ~ vraag & aanbod
▪ = afhankelijk van behoefte
o Coënzyme= PLP = pyridoxal-fosfaat (vit B afgeleide)

MECHANISME PLP/PMP

• Transfer NH2: coënzyme pyridoxal-P => pyridoxamine-P
• intern => extern => interne N

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