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AAB MT HEMATOLOGY EXAM WITH COMPLETE QUESTIONS AND ACCURATE ANSWERS
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AAB MT HEMATOLOGY WITH COMPLETE QUESTIONS AND ACCURATE ANSWERS
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AAB MT HEMATOLOGY WITH COMPLETEQUESTIONS AND ACCURATE ANSWERS
What is methemoglobin? Correct Answer Methemoglobin is a
form of hemoglobin that contains ferric [Fe3+] iron and has a
decreased ability to bind oxygen. However, the ferric iron has an
increased affinity for bound oxygen. When methemoglobin
concentration is elevated in red blood cells, tissue hypoxia can
occur.
What is the function of the enzyme methemoglobin-cytochrome C
reductase in a red blood cell? Correct Answer To keep iron in the
ferrous state
What product is formed when ferrous iron of hemoglobin is
oxidized to the ferric state? Correct Answer Methemoglobin
What is carboxyhemoglobin? Correct Answer A stable complex
of carbon monoxide and hemoglobin that forms in RBCs when
carbon monoxide is inhaled or produced in normal metabolism.
Large quantities of it hinder delivery of O2 to the body. Tobacco
smoking (through carbon monoxide inhalation) raises the blood
levels of COHb by a factor of several times from its normal
concentrations.
Which hemoglobin has a 200 times greater binding capacity for
the hemoglobin molecule than oxygen? Correct Answer
Carboxyhemoglobin
Which hemoglobin derivative causes irreversible changes in
RBCs? Correct Answer Sulfhemoglobin -- makes blood incapable
of carrying oxygen.
,Which of the following hemoglobins is NOT normally present in a
normal adult? Correct Answer Hb-S
Which embryonic hemoglobin is normally found in newborns?
Correct Answer Hb-F
What is the most abundant hemoglobin in a newborn? Correct
Answer Hb-F
What is the molecular structure of Hemoglobin S? Correct Answer
Valine replaces glutamic acid in the 6th position of the beta chain
Which of the following hemoglobins is insoluble under lowered
oxygen tension? Correct Answer Hb-S
What laboratory test is used to confirm the specific diagnosis of
sickle cell anemia? Correct Answer Hemoglobin electrophoresis
In the solubility test for hemoglobin S, what is the reagent
responsible for the reduction of the hemoglobin molecule? Correct
Answer Sodium dithionite
In hemoglobin C, what replaces glutamic acid? Correct Answer
Lysine
Which red blood cell inclusion is characteristic of hemoglobin C
disease? Correct Answer Rod-shaped crystals
What is hemoglobin F composed of? Correct Answer 2 alpha and
2 gamma chains
Which hemoglobin is resistant to alkali denaturation? Correct
Answer Hb-F
, Which hemoglobins are differentiated by the Kleihauer-Betke
technique? Correct Answer Hb-A1 from Hb-F
What is the order of migration of hemoglobins, from fastest to
slowest, on cellulose acetate at pH 8.4? Correct Answer A1, F, S,
C
Why is citrate agar used when abnormal hemoglobins are
identified on cellulose acetate at pH 8.6? Correct Answer It
separates hemoglobin S from hemoglobin D
The cyanmethemoglobin method measures all hemoglobin
pigments EXCEPT which one? Correct Answer Sulfhemoglobin
What is the diluent used in the cyanmethemoglobin method for
the determination of hemoglobin? Correct Answer Drabkin's
solution
What is the normal plasma hemoglobin concentration? Correct
Answer 2-3 mg/dL
Which plasma protein binds free hemoglobin? Correct Answer
Haptoglobin
Which one of the following statements concerning hemolytic
anemia is false? Correct Answer The serum haptoglobin is
increased
In this type of anemia RBCs are normocytic and normochromic.
RBCs, hemoglobin, and hematocrit are decreased and the
indirect bilirubin is increased. Correct Answer Hemolytic anemia
Myoglobin can be separated from hemoglobin by saturating the
specimen with which one of the following reagents? Correct
Answer Ammonium sulfite
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