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AMR EXAM 1 UF QUESTIONS AND ANSWERS

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AMR EXAM 1 UF QUESTIONS AND ANSWERS

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  • September 20, 2024
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220 Multiple choice questions

Term 1 of 220
Lincosamides (lincomycin and clindamycin) bind to the ______ subunit of the _______ bacterial
ribosome, leading to _________ inhibition of protein synthesis

23S, 50S, bacteriostatic


Gram positive bacteria

ParC (breakage-reunion subunit)

Ansamycins, cancer treatment

Term 2 of 220
Rifampicin RNAP complex

Nucleoside triphosphates of each of these bases:
ATP, GDP, CTP, and DTTP.

Potential carcinogen (induces cancer in animal models but exposure in humans not
linked to cancer)

In rare instances can cause Stevens-Johnson syndrome: a severe cutaneous adverse
reaction (also observed with sulfa antibiotics and penicillins). SJS is manifested by rapid
epidermal necrosis (loss of skin tissue)


Severe cutaneous adverse reaction (also observed with sulfa antibiotics and penicillins).
SJS is manifested by rapid epidermal necrosis (loss of skin tissue)


- Crystal structure of RNA polymerase bound with rifampicin molecule

- Rifampicin directly binds in the path of the elongating RNA molecule by a simple steric
block

,Term 3 of 220
Over______ new classes of antibiotics were discovered between 1940 and 1962.


Since 1962 ______ classes of new antibiotics were commercialized

20


Only a few

False, lower chance


Ansamycins, cancer treatment

Tetracyclines

Term 4 of 220
Bacteriostatic

Gram positive bacteria

Inhibits bacterial growth

Rifampin, isoniazid, quinolones

Fecal transfer (90% efficacy)

Term 5 of 220
Genomic High-Throughput Screens period

Genome sequencing methodology was used to predict targets and employed large-
scale screens for novel antibiotics

Alexander Fleming

Ernest Duchesne


Repurposed drugs: initially developed as monoamine oxidase inhibitors for the
treatment of depression •Linezoid approved for clinical use in 2000. First antibiotic with a
completely novel structural class in the past two decades (1980-2000) •Binds to 50S
ribosomal subunit and inhibits the initiation complex

,Term 6 of 220
True or false: the development of novel antibiotics has increased recently

True


False

Term 7 of 220
Waksman's definition of antibiotics

Kidney: aminoglycosides

Liver: carbapenems, rifampin, isoniazid, tetracyclines

Microbial product that kills or inhibits the growth of other microbes.


Active against anaerobic bacteria (bacteria vaginosis, C dificile, H. pylori)

The skeleton structure of beta-lactam antibiotics mimics D-Alanyl-D-Alanine dipeptide
in bacteria

Term 8 of 220
Most widely used antibiotic in agriculture

ParC and ParE

Tetracycline


Beta-lactam

Dihydropterin and PABA

Term 9 of 220
Primordial stages

High toxicity to kidneys, only available as ointment for minor cuts. Is also approved by
FDA inpoultry

Discovery of all major classes of antibiotics

Elongating RNA molecule, simple steric block

Were marked by sulfa drugs and penicillins.

, Term 10 of 220
Antibiotics are responsible for almost _____________ emergency department visits for adverse drug
events

House with an attached garage

Pseudomonas aeruginosa

8 years

1 out of 5

Term 11 of 220
Golden era

3, misfolding aggregation and loss of function

Peptides: Vancomycin and Bacitracin

Cycloserine


Fosfomycin

Kill bacteria or inhibit their growth

Discovery of all major classes of antibiotics

Term 12 of 220
Antibiotic side affect- organ damage

Microbial product that kills or inhibits the growth of other microbes.

Mycin = derived from streptomyces

Micin - derived from micromonospora

Kidney: aminoglycosides

Liver: carbapenems, rifampin, isoniazid, tetracyclines

Mosquitos develop resistance to pesticides, making population control difficult

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