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AMR EXAM 1 UF QUESTIONS AND ANSWERS
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AMR EXAM 1 UF QUESTIONS AND ANSWERS
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Name: Score:220 Multiple choice questions
Term 1 of 220
Lincosamides (lincomycin and clindamycin) bind to the ______ subunit of the _______ bacterial
ribosome, leading to _________ inhibition of protein synthesis
23S, 50S, bacteriostatic
Gram positive bacteria
ParC (breakage-reunion subunit)
Ansamycins, cancer treatment
Term 2 of 220
Rifampicin RNAP complex
Nucleoside triphosphates of each of these bases:
ATP, GDP, CTP, and DTTP.
Potential carcinogen (induces cancer in animal models but exposure in humans not
linked to cancer)
In rare instances can cause Stevens-Johnson syndrome: a severe cutaneous adverse
reaction (also observed with sulfa antibiotics and penicillins). SJS is manifested by rapid
epidermal necrosis (loss of skin tissue)
Severe cutaneous adverse reaction (also observed with sulfa antibiotics and penicillins).
SJS is manifested by rapid epidermal necrosis (loss of skin tissue)
- Crystal structure of RNA polymerase bound with rifampicin molecule
- Rifampicin directly binds in the path of the elongating RNA molecule by a simple steric
block
,Term 3 of 220
Over______ new classes of antibiotics were discovered between 1940 and 1962.
Since 1962 ______ classes of new antibiotics were commercialized
20
Only a few
False, lower chance
Ansamycins, cancer treatment
Tetracyclines
Term 4 of 220
Bacteriostatic
Gram positive bacteria
Inhibits bacterial growth
Rifampin, isoniazid, quinolones
Fecal transfer (90% efficacy)
Term 5 of 220
Genomic High-Throughput Screens period
Genome sequencing methodology was used to predict targets and employed large-
scale screens for novel antibiotics
Alexander Fleming
Ernest Duchesne
Repurposed drugs: initially developed as monoamine oxidase inhibitors for the
treatment of depression •Linezoid approved for clinical use in 2000. First antibiotic with a
completely novel structural class in the past two decades (1980-2000) •Binds to 50S
ribosomal subunit and inhibits the initiation complex
,Term 6 of 220
True or false: the development of novel antibiotics has increased recently
True
False
Term 7 of 220
Waksman's definition of antibiotics
Kidney: aminoglycosides
Liver: carbapenems, rifampin, isoniazid, tetracyclines
Microbial product that kills or inhibits the growth of other microbes.
Active against anaerobic bacteria (bacteria vaginosis, C dificile, H. pylori)
The skeleton structure of beta-lactam antibiotics mimics D-Alanyl-D-Alanine dipeptide
in bacteria
Term 8 of 220
Most widely used antibiotic in agriculture
ParC and ParE
Tetracycline
Beta-lactam
Dihydropterin and PABA
Term 9 of 220
Primordial stages
High toxicity to kidneys, only available as ointment for minor cuts. Is also approved by
FDA inpoultry
Discovery of all major classes of antibiotics
Elongating RNA molecule, simple steric block
Were marked by sulfa drugs and penicillins.
, Term 10 of 220
Antibiotics are responsible for almost _____________ emergency department visits for adverse drug
events
House with an attached garage
Pseudomonas aeruginosa
8 years
1 out of 5
Term 11 of 220
Golden era
3, misfolding aggregation and loss of function
Peptides: Vancomycin and Bacitracin
Cycloserine
Fosfomycin
Kill bacteria or inhibit their growth
Discovery of all major classes of antibiotics
Term 12 of 220
Antibiotic side affect- organ damage
Microbial product that kills or inhibits the growth of other microbes.
Mycin = derived from streptomyces
Micin - derived from micromonospora
Kidney: aminoglycosides
Liver: carbapenems, rifampin, isoniazid, tetracyclines
Mosquitos develop resistance to pesticides, making population control difficult
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