Term 1 of 220
Lincosamides (lincomycin and clindamycin) bind to the ______ subunit of the _______ bacterial
ribosome, leading to _________ inhibition of protein synthesis
23S, 50S, bacteriostatic
Gram positive bacteria
ParC (breakage-reunion subunit)
Ansamycins, cancer treatment
Term 2 of 220
Rifampicin RNAP complex
Nucleoside triphosphates of each of these bases:
ATP, GDP, CTP, and DTTP.
Potential carcinogen (induces cancer in animal models but exposure in humans not
linked to cancer)
In rare instances can cause Stevens-Johnson syndrome: a severe cutaneous adverse
reaction (also observed with sulfa antibiotics and penicillins). SJS is manifested by rapid
epidermal necrosis (loss of skin tissue)
Severe cutaneous adverse reaction (also observed with sulfa antibiotics and penicillins).
SJS is manifested by rapid epidermal necrosis (loss of skin tissue)
- Crystal structure of RNA polymerase bound with rifampicin molecule
- Rifampicin directly binds in the path of the elongating RNA molecule by a simple steric
block
,Term 3 of 220
Over______ new classes of antibiotics were discovered between 1940 and 1962.
Since 1962 ______ classes of new antibiotics were commercialized
20
Only a few
False, lower chance
Ansamycins, cancer treatment
Tetracyclines
Term 4 of 220
Bacteriostatic
Gram positive bacteria
Inhibits bacterial growth
Rifampin, isoniazid, quinolones
Fecal transfer (90% efficacy)
Term 5 of 220
Genomic High-Throughput Screens period
Genome sequencing methodology was used to predict targets and employed large-
scale screens for novel antibiotics
Alexander Fleming
Ernest Duchesne
Repurposed drugs: initially developed as monoamine oxidase inhibitors for the
treatment of depression •Linezoid approved for clinical use in 2000. First antibiotic with a
completely novel structural class in the past two decades (1980-2000) •Binds to 50S
ribosomal subunit and inhibits the initiation complex
,Term 6 of 220
True or false: the development of novel antibiotics has increased recently
Mosquitos develop resistance to pesticides, making population control difficult
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller selftest. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $9.00. You're not tied to anything after your purchase.