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NAPLEX Excipients Exam Questions and Answers 2024/2025( A+ GRADED 100% VERIFIED).
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NAPLEX Excipients Exam Questions and Answers 2024/2025( A+ GRADED 100% VERIFIED).
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NAPLEX ExcipientsCalculate the minimum weighable quantity (MWQ) - ANS MWQ = sensitivity requirement /
percentage of error
When is a glass mortar and pestle used? - ANS Liquids
Compounds that are oily or can stain
When is a wedgewood mortar and pestle used? - ANS Grinding dry crystals and hard powders
When is a porcelain mortar and pestle preferred? - ANS Blending powders
Pulverizing gummy consistencies
Describe the compounding preparation steps - ANS 1. calculate the quantities, gather
components and supplies, check/clean equipment
2. garb and wash hands
3. make according to the master formulation record
What is communion? - ANS Reduction of particle size by grinding, crushing, milling, vibrating,
or other processes
What are the 3 main methods of comminution? - ANS Trituration
Levigation and spatulation
Pulverization by intervention
Describe trituration - ANS Generally means to "mix thoroughly" or make homogenous
Ex. grinding tablets in a mortar and pestle until a fine powder is achieved
Ex. shaking an emulsion
Describe levigation - ANS Incorporating a small amount of liquid with a powder to form a
uniform paste and help the grinding process
Describe spatulation - ANS Similar to levigation but performed on an ointment slab
Describe pulverization by intervention - ANS Used for crystalline powders that do not crush
easily. The crystals are dissolved with an intervening solvent and mixed until the solvent
evaporates. When the powder recrystallizes, the particles are finer and easier to work with
What is an HLB number? - ANS Used to describe the hydrophilic-lipophilic balance (HLB) of a
surfactant
, Describe what an HLB < 10 means - ANS Lower number = lipophilic
use in a water/oil emulsion
Describe what an HLB > 10 means - ANS Higher number = hydrophilic
use in a oil/water emulsion
Describe the dry gum method of making an emulsion - ANS 4 parts oil: 2 parts water: 1 part
emulsifier
Levigate the gum with the oil, then add water all at once. shake mixture to triturate until a
cracking sound is heard and the mixture looks creamy white
Describe the wet gum method of making an emulsion - ANS 4 parts oil: 2 parts water: 1 part
emulsifier
Triturate the gum and water to form a mucilage, then add the oil slowly while titurating
Excipient - too keep the powder dry - ANS Adsorbents
Magnesium oxide/carbonate
Kaolin
Excipient - breaks up and inhibits the formation of foams - ANS Anti-foaming agent
Simethicone
Excipient - prevents oxidation - ANS Antioxidants
Ascorbic acid
Sodium ascorbate/bisulfate/sulfoxylate/thiosulfate
Excipient - adhesive materials to hold powders together - ANS Binders
Acacia
Starch paste
Sucrose syrup
Excipient - maintain the formulation within the acceptable pH range - ANS Buffers
Potassium phosphate
Sodium acetate
Excipient - prevents degradation due to oxygen, light, moisture and masks unpalatable taste -
ANS Coatings
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