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CMB Antibodies Exam
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CMB1003 22-23 Antibodies Exam 2024-2025What is the other name for antibodies? -Answer Immunoglobulins
What is an antibody? -Answer Large, Y-shaped secreted glycoproteins that bind to
specific antigens from individual pathogens
What do antibodies/immunoglobulins abbreviate to? -Answer Ig
What is an antigen? -Answer a toxin or other foreign substance that induces an immune
response in the body, especially the production of antibodies.
What does Ags abbreviate to? -Answer Antigen
What cells are antibodies produced by? - Answer Mature B lymphocytes
True or false, antibodies have been shown to bind to proteins, polysaccharides, lipids,
nucleic acids, chemicals and metals - Answer True
What is the basic structure of an antibody? - Answer 2 heavy chains and 2 light chains
joined by non-covalent interactions and disulphide bridges
Is the N-terminal of each chain on an antibody variable or constant? - Answer Variable
Is the C-terminal of each chain on an antibody variable or constant? - Answer Constant
What do antibodies first express as in developing (immature) B cells? - Answer
Membrane-bound B cell antigen receptors (BCR)
, What does it mean that antibodies are bivalent? - Answer Can bind 2 antigens at once as
has tow binding sites
How many domains are antibodies made of? - Answer 12
What are the 2 regions of an antibody? - Answer Fab and Fc
What does FAB fragment stand for? - Answer fragment antigen binding fragment
True or false, purified Fab fragments are still able to bind antigens? - Answer True
What does Fc fragment stand for? - Answer Fragment crystallisable fragment
The Fab regions of antibodies bind to what on the pathogens antigen? - Answer Epitopes
What is an epitope? - This is the part of an antigen molecule to which an antibody
attaches itself
Are epitopes linear or conformational? - They can be either
What allows antibodies to bind antigens with very high affinities? - It is the combination
of a unique structure of the Fab region found on each different antibody along with the
range of non-covalent forces that allows this to take place.
Why are the forces that act between antigens and antibodies different types? - Answer
Because antibodies will always be made of amino acids, however antigens can be made
of a variety of molecules
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