Exam (elaborations)
NURS 8024 Pharm Test 3 Pt. 1: Questions & Solutions
- Course
- Institution
NURS 8024 Pharm Test 3 Pt. 1: Questions & Solutions
[Show more]
Content preview
NURS 8024 Pharm Test 3 Pt. 1: Questions & SolutionsNarrow spectrum Right Ans - act on a single or limited group of pathogens
Extended-spectrum Right Ans - "Efficacy against large numbers of gram
positive / gram negative organisms"
Broad-spectrum Right Ans - *empiric-presumptive therapy
*effective against "broad spectrum" of microbes
*unknown pathogen-possible life threatening infection
*risk for super infections
Drug entry affected by multiple factors: Right Ans - 1. lipid solubility
2. protein binding
3. molecular weight
4. inflammation
Susceptibility testing Right Ans - -guides antimicrobial therapy
-zone of inhibition
-predicts minimum inhibitory concentration (MIC); estimate of the drug
sensitivity of pathogens
Minimum inhibitory concentration (MIC) Right Ans - Interpretation
categorizes result as Susceptible, Intermediate, Resistant
Susceptible (S) Right Ans - bacterial strain susceptible when pathogen
inhibited in vitro by a concentration of drug associated with a high likelihood
of therapeutic success
Intermediate (I) Right Ans - Sensitivity termed intermediate when
concentration of drug associated with uncertain therapeutic effect
Resistant (R) Right Ans - bacterial strain considered resistant when
concentration of the drug associated with a high likelihood of therapeutic
failure
Bacteriostatic Right Ans - -inhibits growth or multiplication of bacteria
-limits spread of infection - enables immune system to effectively attack
pathogen
, Bactericidal Right Ans - -kills bacteria
-total number of viable organisms decreases
Concentration-dependent killing Right Ans - -increase kill rate with
increase concentration
-once daily dose
-aminoglycosides, quinolones
Time-dependent killing Right Ans - • bactericidal activity dependent on
time serum concentration ↑ MBC predicts efficacy
• AUC / MIC ratio
• More frequent dosing
• β lactams, macrolides, vancomycin
Beta lactams (PCN, cephalosporins, and Vanc) Right Ans - Inhibitor of cell
wall synthesis
Tetracyclines, aminoglycosides, macrolides Right Ans - Inhibitor of protein
synthesis
MOA of fluoroquinolones Right Ans - Inhibitor of nucleic acid function or
synthesis
Sulfonamides and Trimethoprim Right Ans - Inhibitors of metabolism
Beta-lactam antibiotics Right Ans - -inhibit cell wall synthesis
-bactericidal
-V common Rx
Beta-lactam pharmacokinetics Right Ans - -Time dependent killing
-short half life
-IV: 100% bioavailability
-PO: variable absorption rate and degree affected by FOOD
What Beta-lactams can penetrate the CSF? Right Ans - -3rd and 4th
generation cephalosporins, aztreonam, meropenem, (parenteral)
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller LeCrae. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $9.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
81989 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now